Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years

被引：2

作者：

Vega-Piris, Lorena ^{[1
]}

Carretero, Silvia Galindo ^{[1
]}

Mayordomo, Jose Luis ^{[2
]}

Zarzuelo, Merecedes Belen Rumayor ^{[3
]}

Rio, Virginia Alvarez ^{[4
,5
]}

Garcia, Virtudes Gallardo ^{[6
]}

Vazquez, Miriam Garcia ^{[7
]}

Rodriguez, Maria del Carmen Garcia ^{[8
,11
]}

Basile, Luca ^{[9
]}

Gonzalez-Coviella, Nives Lopez ^{[10
]}

Boada, Maria Isabel Barranco ^{[11
]}

Perez-Martinez, Olaia ^{[12
]}

Azevedo, Ana Lameiras

Rubio, Carmen Quinones ^{[13
]}

Duran, Jaume Gimenez ^{[14
]}

Ibanez, Ana Fernandez ^{[15
]}

Rivera, Maria Victoria Garcia ^{[16
]}

Marin, Violeta Ramos ^{[17
]}

Castrillejo, Daniel ^{[18
]}

Raymundo, Luis Javier Viloria ^{[19
]}

Larrauri, Amparo ^{[1
,20
]}

Monge, Susana ^{[1
,21
]}

机构：

[1] Inst Hlth Carlos III, Natl Ctr Epidemiol, Dept Communicable Dis, Calle Melchor Fernandez Almagro 5, Madrid 28029, Spain

[2] Gen Univ Hosp Consortium Valencia, Valencian Community, Valencia, Spain

[3] Reg Minist Hlth Madrid, Directorate Gen Publ Hlth, Madrid, Spain

[4] Gen Directorate Publ Hlth, Healthcare Dept, Epidemiol Serv, Castilla, Spain

[5] Gen Directorate Publ Hlth, Healthcare Dept, Epidemiol Serv, Leon, Spain

[6] Minist Hlth & Consumer Andalucia, Occupat Hlth & Surveillance Serv, Directorate Gen Publ Hlth & Pharmaceut Regulat, Andalucia, Spain

[7] Govt Aragon, Dept Hlth, Epidemiol Surveillance, Directorate Gen Publ Hlth, Zaragoza, Spain

[8] Extremadura Hlth Serv, Epidemiol Surveillance, Directorate Gen Publ Hlth, Merida, Spain

[9] Publ Hlth Agcy Catalonia, Dept Hlth, Barcelona, Spain

[10] Canary Hlth Serv, Epidemiol Surveillance Unit, Directorate Gen Publ Hlth, Canarias Isl, Spain

[11] Gen Directorate Publ Hlth & Addict, Hlth Dept, Epidemiol Serv, Murcia, Spain

[12] Reg Govt Galicia, Minist Hlth, Epidemiol Serv, Directorate Gen Publ Hlth, Santiago, Spain

[13] Directorate Gen Publ Hlth Consumer & Care La Rioj, Epidemiol & Hlth Prevent Serv, Logrono, Spain

[14] Hlth Res Inst Balear Isl IdISBa, Balearic Isl, Spain

[15] Publ Hlth Asturias, Epidemiol Surveillance Serv, Balearic Isl, Spain

[16] Minist Hlth Castilla La Mancha, Epidemiol Serv Technician, Gen Directorate Publ Hlth, La Mancha, Spain

[17] Council Hlth, Dept Epidemiol Surveillance, Ceuta, Spain

[18] Directorate Gen Publ Hlth, Minist Social Pol & Publ Hlth Melilla, Epidemiol Surveillance, Melilla, Spain

[19] Minist Hlth Cantabria, Epidemiol Surveillance Sect, Gen Directorate Publ Hlth, Cantabria, Spain

[20] CIBER Epidemiol & Publ Hlth, Madrid, Spain

[21] CIBER Infect Dis, Madrid, Spain

来源：

JOURNAL OF INFECTION | 2024年 / 89卷 / 05期

关键词：

Severe acute respiratory infection; Syncytial respiratory virus; Influenza; SARS-CoV2; ICU admission; Pneumonia; Mortality; Vaccination; COMMUNITY-ACQUIRED PNEUMONIA; STATES; COVID-19;

D O I：

10.1016/j.jinf.2024.106292

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Introduction: Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals >= 65 years old admitted to hospital with RSV, compared to influenza or COVID-19. Methods: We included hospitalised patients from Severe Acute Respiratory Infection Surveillance in Spain between 2021-2024, aged >= 65 years, laboratory confirmed for RSV, influenza or SARS-CoV-2. Using a binomial regression with logarithmic link, we estimated the relative risk (RR) of pneumonia, ICU admission and in-hospital mortality, in patients with RSV compared to influenza or SARS-CoV-2, adjusting for age, sex, season and comorbidities. We stratified the estimates by vaccination status for influenza or SARS-CoV2. Results: Among patients unvaccinated for influenza or SARS-CoV-2, those with RSV had similar or lower risk of pneumonia [vs. influenza: RR= 0.91 (95% Confidence Interval: 0.72-1.16); vs. SARS-CoV-2: 0.81 (0.67-0.98)], ICU admission [vs. influenza: 0.93 (0.41-2.08); vs. SARS-CoV-2: 1.10 (0.61-1.99)] and mortality [vs. influenza: 0.64 (0.32-1.28); vs. SARS-CoV-2: 0.56 (0.30-1.04)]. Among the vaccinated, results were largely similar except for a higher risk of ICU admission with RSV [vs. influenza: 2.13(1.16-3.89); vs. SARSConclusions: RSV presented similar or lower intrinsic severity than influenza or SARS-CoV2. Among vaccinated patients, RSV was associated to higher ICU-admission, suggesting the potential for preventive RSV vaccination. (c) 2024 The Authors. Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页数：7

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