Emerging role of mesenchymal stem cell-derived exosomes in the repair of acute kidney injury

被引：2
作者：
Wang, Juan-Juan [1 ]
Zheng, Yu [1 ]
Li, Yan-Lin [1 ]
Xiao, Yin [2 ]
Ren, Yang-Yang [3 ]
Tian, Yi-Qing [4 ]
机构：
[1] Nanjing Univ, Peoples Hosp Yancheng 1, Yancheng Hosp 1, Clin Lab,Affiliated Hosp,Med Sch, Yancheng 224000, Jiangsu, Peoples R China
[2] Xuzhou Med Univ, Dept Med Imaging, Affiliated Xuzhou Municipal Hosp, Xuzhou 221000, Jiangsu, Peoples R China
[3] Xinyi Peoples Hosp, Clin Lab, Xuzhou 221000, Jiangsu, Peoples R China
[4] Xuzhou Cent Hosp, Clin Lab, 199 Jiefang South Rd, Xuzhou 221000, Jiangsu, Peoples R China
来源：
WORLD JOURNAL OF STEM CELLS | 2025年 / 17卷 / 03期
关键词：
Mesenchymal stem cells; Exosomes; Delivery of molecules; Acute kidney injury; Repair; ACUTE-RENAL-FAILURE; BONE-MARROW; ADIPOSE-TISSUE; GROWTH-FACTOR; CISPLATIN; PATHOPHYSIOLOGY; AUTOPHAGY; VESICLES; THERAPY; PROTECT;
D O I：
10.4252/wjsc.v17.i3.103360
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid deterioration in kidney function and has a significant impact on patient health and survival. Mesenchymal stem cells (MSCs) have the potential to enhance renal function by suppressing the expression of cell cycle inhibitors and reducing the expression of senescence markers and microRNAs via paracrine and endocrine mechanisms. MSC-derived exosomes can alleviate AKI symptoms by regulating DNA damage, apoptosis, and other related signaling pathways through the delivery of proteins, microRNAs, long-chain noncoding RNAs, and circular RNAs. This technique is both safe and effective. MSC-derived exosomes may have great application prospects in the treatment of AKI. Understanding the underlying mechanisms will foster the development of new and promising therapeutic strategies against AKI. This review focused on recent advancements in the role of MSCs in AKI repair as well as the mechanisms underlying the role of MSCs and their secreted exosomes. It is anticipated that novel and profound insights into the functionality of MSCs and their derived exosomes will emerge.
引用
收藏
页数：13
相关论文
共 98 条
[1]   Human mesenchymal stem cells modulate allogeneic immune cell responses [J].
Aggarwal, S ;
Pittenger, MF .
BLOOD, 2005, 105 (04) :1815-1822
[2]   Study of Bone Marrow Mesenchymal and Tendon-Derived Stem Cells Transplantation on the Regenerating Effect of Achilles Tendon Ruptures in Rats [J].
Al-ani, Mohanad Kh ;
Xu, Kang ;
Sun, Yanjun ;
Pan, Lianhong ;
Xu, ZhiLing ;
Yang, Li .
STEM CELLS INTERNATIONAL, 2015, 2015
[3]   Adipose Tissue-Derived Stem Cells: Immunomodulatory Effects and Therapeutic Potential [J].
Al-Ghadban, Sara ;
Bunnell, Bruce A. .
PHYSIOLOGY, 2020, 35 (02) :125-133
[4]   Acute Kidney Injury as a Condition of Renal Senescence [J].
Andrade, Lucia ;
Rodrigues, Camila E. ;
Gomes, Samirah A. ;
Noronha, Irene L. .
CELL TRANSPLANTATION, 2018, 27 (05) :739-753
[5]   Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth [J].
Anil, Sukumaran ;
Thomas, Nebu G. ;
Chalisserry, Elna P. ;
Dalvi, Yogesh B. ;
Ramadoss, Ramya ;
Vellappally, Sajith .
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2024, (207)
[6]   Pathophysiology of Acute Kidney Injury [J].
Basile, David P. ;
Anderson, Melissa D. ;
Sutton, Timothy A. .
COMPREHENSIVE PHYSIOLOGY, 2012, 2 (02) :1303-1353
[7]   Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group [J].
Bellomo, R ;
Ronco, C ;
Kellum, JA ;
Mehta, RL ;
Palevsky, P .
CRITICAL CARE, 2004, 8 (04) :R204-R212
[8]   Mesenchymal Stem Cells Secrete Multiple Cytokines That Promote Angiogenesis and Have Contrasting Effects on Chemotaxis and Apoptosis [J].
Boomsma, Robert A. ;
Geenen, David L. .
PLOS ONE, 2012, 7 (04) :e35685
[9]   Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury [J].
Bruno, Stefania ;
Grange, Cristina ;
Deregibus, Maria Chiara ;
Calogero, Raffaele A. ;
Saviozzi, Silvia ;
Collino, Federica ;
Morando, Laura ;
Busca, Alessandro ;
Falda, Michele ;
Bussolati, Benedetta ;
Tetta, Ciro ;
Camussi, Giovanni .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (05) :1053-1067
[10]   Mesenchymal stromal cell potency to treat acute kidney injury increased by ultrasound-activated interferon-γ/interleukin-10 axis [J].
Burks, Scott R. ;
Nagle, Matthew E. ;
Bresler, Michele N. ;
Kim, Saejeong J. ;
Star, Robert A. ;
Frank, Joseph A. .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2018, 22 (12) :6015-6025
12345678910