Postmortem findings of organ damage in novel psychoactive substances users: A comprehensive review

被引：0

作者：

Benedetti, Beatrice ^{[1
,2
]}

Conte, Celeste ^{[1
,2
]}

Bergamin, Eva ^{[1
,2
]}

Di Santo, Riccardo ^{[1
,3
,9
]}

Ciasca, Gabriele ^{[1
,3
,9
]}

Corkery, John M. ^{[4
,8
]}

Bassi, Marta ^{[5
,6
]}

Corli, Giorgia ^{[5
,6
]}

Bilel, Sabrine ^{[5
,6
]}

Schifano, Fabrizio ^{[4
,8
]}

Marti, Matteo ^{[5
,6
,7
]}

De-Giorgio, Fabio ^{[1
,2
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy

[2] Univ Cattolica Sacro Cuore, Dept Healthcare Surveillance & Bioeth, Sect Legal Med, Rome, Italy

[3] Univ Cattolica Sacro Cuore, Dipartimento Neurosci, Sez Fis, I-00168 Rome, Italy

[4] Univ Hertfordshire, Drug Misuse & Novel Psychoact Subst Res Unit, Psychopharmacol, Hatfield AL10 9AB, England

[5] Univ Ferrara, Dept Translat Med, Sect Legal Med, Ferrara, Italy

[6] Univ Ferrara, LTTA Ctr, Ferrara, Italy

[7] Presidency Council Ministers, Collaborat Ctr Italian Natl Early Warning Syst, Dept Antidrug Pol, Rome, Italy

[8] Univ Brescia, Dipartimento Sci Clin & Sperimentali, Brescia, Italy

[9] Fdn Policlin Univ A Gemelli IRCCS, I-00168 Rome, Italy

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2024年 / 167卷

关键词：

Novel psychoactive substances (NPS); Synthetic opioids; Synthetic cannabinoids; Cathinones; Substance abuse; Polydrug use; Autopsy; METHYLENEDIOXYPYROVALERONE BATH SALTS; TANDEM MASS-SPECTROMETRY; 2 FATAL INTOXICATIONS; LC-MS-MS; SYNTHETIC CANNABINOIDS; TOXICOLOGICAL FINDINGS; ACETYL FENTANYL; ALPHA-PYRROLIDINOVALEROPHENONE; DESIGNER DRUGS; LIQUID-CHROMATOGRAPHY;

D O I：

10.1016/j.neubiorev.2024.105927

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Introduction: Despite the rising number of NPS-related deaths, comprehensive data on their prevalence, identification, and associated organ damage remain scarce. Materials and methods: A literature search was conducted. Predefined inclusion and exclusion criteria were applied, resulting in the identification of 197 articles. Results: We identified 446 cases of NPS-related deaths, involving a total of 176 different substances. Synthetic opioids were the most prevalent class (34 %), followed by synthetic cannabinoids (22 %) and cathinones (21 %). Co-ingestion of NPS with other substances occurred in 77 % of cases. Macroscopic findings varied across organs, with congestion and edema most observed in the brain (23 %) and lung (56 %), respectively. Discussion: The existing literature lacks comprehensive descriptions of organs subjected to autopsy and histological examination in NPS-positive subjects. Despite this limitation, our findings underscore the prominence of lung pathology. Moreover, the prevalence of normal organs in cases of acute intoxication is a significant observation. We advocate for future research to provide more detailed insights to enhance our understanding of the multifaceted landscape of NPS-related deaths.

引用

页数：12