ADDITIVITY OF ACTION BETWEEN POLYSORBATE 80 AND POLYMYXIN-B TOWARDS SPHEROPLASTS OF PSEUDOMONAS-AERUGINOSA NCTC-6750

被引：12

作者：

BROWN, MRW ^{[1
]}

GEATON, EM ^{[1
]}

GILBERT, P ^{[1
]}

机构：

[1] UNIV ASTON, DEPT PHARM, MICROBIOL RES GRP, BIRMINGHAM B4 7ET, W MIDLANDS, ENGLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1979年 / 31卷 / 03期

关键词：

D O I：

10.1111/j.2042-7158.1979.tb13463.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

When polymyxin B and polysorbate 80 were used together against spheroplasts of P. aeruginosa, the activities were additive. These substances were previously reported to act synergistically against P. aeruginosa, but little or no intrinsic activity towards intact cells has been attributed to polysorbate 80. In addition to enhancing polymyxin B penetration to the cytoplasmic membrane, polysorbate 80 may also act as an antimicrobial agent when polymyxin-induced damage to the outer membrane facilitates the surfactant''s passage through the cell envelope.

引用

页码：168 / 170

页数：3

共 18 条

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