Brain diffusion tensor imaging changes linked to the split hand phenomenon in amyotrophic lateral sclerosis

被引：0

作者：

Seol-Hee Baek ^{[1
]}

Woo-Suk Tae ^{[2
]}

Dorothee Auer ^{[3
]}

Byung-Jo Kim ^{[4
]}

机构：

[1] Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, 73, Goryeodae-ro, Seongbuk-gu, Seoul

[2] Brain Convergence Research Center, Korea University College of Medicine, 73, Goryeodae-ro, Seongbuk-gu, Seoul

[3] Division of Mental Health and Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham

[4] Sir Peter Mansfield Imaging Center, School of Medicine, University of Nottingham, Nottingham

[5] Nottingham Biomedical Research Center, National Institute for Health Research, Queens Medical Center, Nottingham

[6] BK21 FOUR Program in Learning Health Systems, Korea University, Seoul

来源：

Scientific Reports | / 15卷 / 1期

关键词：

Amyotrophic lateral sclerosis; Axonal degeneration; Corticospinal tract; Diffusion tensor imaging; Pathophysiology; Split-hand phenomenon;

D O I：

10.1038/s41598-025-97666-0

中图分类号：

学科分类号：

摘要：

The split-hand phenomenon is an early and specific feature of amyotrophic lateral sclerosis (ALS). This study aimed to investigate whether the split-hand phenomenon in ALS is associated with the white matter degeneration of the brain. Patients diagnosed with clinically definite or probable ALS were prospectively recruited and underwent both nerve conduction studies to assess the split-hand index (SHI) and brain diffusion tensor imaging (DTI). Demographic, clinical, and electrophysiological data were all collected. A total of 35 patients with ALS (18 male; median age, 66.0 years) were enrolled in this study. The axial diffusivity (AD) and mode of anisotropy (MO) values of DTI in the corticospinal tract (CST) positively correlated with the SHI. However, there were no significant correlations between the SHI and the fraction anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) scalars. In addition, patients having ALS with bilateral split-hand phenomenon showed reduced AD values in the left CST and reduced MO values in the bilateral CST compared with those without the split-hand phenomenon. However, there were no significant differences in FA, MD, and RD scalars. Our findings suggest that the split-hand phenomenon is associated with degenerative brain changes, particularly in the CST. © The Author(s) 2025.

引用

共 43 条

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