Association of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism with Osteosarcoma in a Mexican Population

被引：0

作者：

Enriquez-Maldonado, Irma G. ^{[1
]}

Montes-Galindo, Daniel A. ^{[2
]}

Ortiz-Lopez, Rocio ^{[3
]}

Ojeda-Ibarra, Jesus ^{[4
]}

Martinez-Fierro, Margarita L. ^{[5
]}

Rodriguez-Sanchez, Iram P. ^{[6
]}

Rojas-Martinez, Augusto ^{[3
]}

Zavala-Pompa, Angel ^{[4
]}

Sanchez-Ramirez, Carmen Alicia ^{[7
]}

Hernandez-Rangel, Alejandra E. ^{[7
]}

Sanchez-Meza, Karmina ^{[7
]}

Garza-Veloz, Idalia ^{[5
]}

Rodriguez-Hernandez, Alejandrina ^{[7
]}

Delgado-Enciso, Ivan ^{[1
,7
,8
]}

机构：

[1] Hlth Serv Mexican Social Secur Inst Welf IMSS BIEN, State Cancerol Inst Colima, Colima 28085, Mexico

[2] Univ Colima, Fac Chem Sci, Coquimatlan 28400, Mexico

[3] Tecnol Monterrey, Escuela Med & Ciencias Salud, Monterrey 64710, Mexico

[4] Monterrey Specialty Hosp 25 IMSS, Dept Pathol Anat, Monterrey 64460, Mexico

[5] Autonomous Univ Zacatecas, Acad Unit Human Med & Hlth Sci, Zacatecas 98160, Mexico

[6] Autonomous Univ Nuevo Leon, Sch Biol Sci, Mol & Struct Physiol Lab, San Nicolas De Los Garza 66455, Mexico

[7] Univ Colima, Sch Med, Colima 28040, Mexico

[8] Florida Int Univ, Robert Stempel Coll Publ Hlth & Social Work, Miami, FL 33199 USA

来源：

PEDIATRIC REPORTS | 2024年 / 16卷 / 03期

关键词：

methylenetetrahydrofolate reductase; osteosarcoma; folic acid; Mexico; single-nucleotide polymorphism; BONE-MINERAL DENSITY; METHOTREXATE-INDUCED TOXICITY; HIGH-DOSE METHOTREXATE; ACUTE LYMPHOBLASTIC-LEUKEMIA; ONE-CARBON METABOLISM; GENE POLYMORPHISM; C677T POLYMORPHISM; FOLATE; SUSCEPTIBILITY; CANCER;

D O I：

10.3390/pediatric16030066

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The methylenetetrahydrofolate reductase (MTHFR) gene 677C -> T polymorphism is capable of altering folate metabolism and can modify certain neoplasia risk. Reports have suggested that folate can have an influence on bone development and so it is of interest to know if the MTHFR 677C -> T polymorphism is associated with the malignant transformation process of this tissue. The polymorphism was determined in 55 patients with osteosarcoma and in 180 healthy individuals. Compared with C/T+C/C genotypes, a 3.7-fold reduction in osteosarcoma probability is possible with the T/T genotype (OR 0.27, CI 95% 0.07-0.82). Undoubtedly, further studies, utilizing large samples and carried out on different populations, are necessary to confirm these results.

引用

页码：786 / 793

页数：8

共 58 条

[1]

Santos FAB, 2020, GENET MOL BIOL, V43, DOI [10.1590/1678-4685-GMB-2019-0380, 10.1590/1678-4685-gmb-2019-0380]

[2] Association Between Folate and Health Outcomes: An Umbrella Review of Meta-Analyses [J].

Bo, Yacong ;

Zhu, Yongjian ;

Tao, Yuchang ;

Li, Xue ;

Zhai, Desheng ;

Bu, Yongjun ;

Wan, Zhongxiao ;

Wang, Ling ;

Wang, Yuming ;

Yu, Zengli .

FRONTIERS IN PUBLIC HEALTH, 2020, 8

[3] Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women [J].

Cagnacci, A ;

Baldassari, F ;

Rivolta, G ;

Arangino, S ;

Volpe, A .

BONE, 2003, 33 (06) :956-959

[4] Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation [J].

Cagnacci, Angelo ;

Bagni, Bruno ;

Zini, Annalisa ;

Cannoletta, Marianna ;

Generali, Matteo ;

Volpe, Annibale .

BONE, 2008, 42 (02) :314-320

[5] Therapy for osteosarcoma: Where do we go from here? [J].

Chou A.J. ;

Geller D.S. ;

Gorlick R. .

Pediatric Drugs, 2008, 10 (5) :315-327

[6]

Cortese C, 2001, Public Health Nutr, V4, P493

[7] Folate levels and N5,N10-methylenetetrahydrofolate reductase genotype (MTHFR) in mothers of offspring with neural tube defects:: A case-control study [J].

de Villarreal, LEM ;

Delgado-Enciso, I ;

Valdéz-Leal, R ;

Ortíz-López, R ;

Rojas-Martínez, A ;

Limón-Benavides, C ;

Sánchez-Peña, MA ;

Ancer-Rodríguez, J ;

Barrera-Saldaña, HA ;

Villarreal-Pérez, JZ .

ARCHIVES OF MEDICAL RESEARCH, 2001, 32 (04) :277-282

[8]

Dean A., 2011, Epi InfoTM, a Database and Statistics Program for Public Health Professionals

[9]

Dean L., 2012, Medical genetics summaries

[10]

Delgado-Enciso I, 2006, REV INVEST CLIN, V58, P462

← 1 2 3 4 5 6 →