Development of Mutant AAV-DJ Capsids with Better Transduction Efficiency for Local and Systemic Delivery

被引：0
|
作者：
Duzenli, Ozgun Firat [1 ]
Zhang Lianwen [2 ]
Peng, Kah-Whye [2 ]
Aslanidi, George [1 ]
机构：
[1] Univ Minnesota, Hormel Inst, Austin, MN USA
[2] Mayo Clin, Rochester, MN USA
来源：
MOLECULAR THERAPY | 2024年 / 32卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
1451
引用
收藏
页码：685 / 685
页数：1
相关论文
共 50 条
  • [41] High expression and therapeutic efficiency of systemic delivery of a dual AAV strategy in a murine model for dysferlin deficiencies
    Pryadkina, M.
    Lostal, W.
    Bourg, N.
    Charton, K.
    Roudaut, C.
    Hirsch, M. L.
    Richard, I.
    HUMAN GENE THERAPY, 2015, 26 (10) : A74 - A74
  • [42] Study of an AAV-8 Capsid Mutant with Direct Heparin Binding Capability but Reduced Efficiency in Liver-Targeted Transduction
    Shen, Xuan
    Xu, Hui
    Storm, Theresa
    Kay, Mark A.
    MOLECULAR THERAPY, 2006, 13 : S44 - S45
  • [43] Assessment of transduction efficiency and tropism of different adeno-associated virus (AAV) serotypes based on route of delivery in rats
    Han, Ian C.
    Jiao, Chunhua
    Kaalberg, Emily E.
    Bhattarai, Sajag
    Burnight, Erin R.
    Tucker, Budd A.
    Mullins, Robert F.
    Stone, Edwin M.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2018, 59 (09)
  • [44] Evaluation of AAV transduction efficiency via multiple delivery routes: Insights from peripheral and central nervous system analysis
    Lee, Na Kyung
    Na, Duk L.
    Kim, Jong-Wan
    Lee, Bumwhee
    Kim, Hee Jin
    Jang, Hyemin
    Lee, Jeehun
    Chang, Jong Wook
    NEUROSCIENCE, 2025, 573 : 96 - 103
  • [45] A Novel AAV9 Mutant with a Remarkably Short Circulation Half Life Leads to Exclusive Liver Transduction Following Systemic Administration
    Rajagopal, Pratheppa
    Nishi, Teruyuki
    Adachi, Kei
    Dillon, Jessica
    Sairavi, Anusha
    Nakai, Hiroyuki
    MOLECULAR THERAPY, 2024, 32 (04) : 261 - 261
  • [46] Systemic Delivery of Self-Complementary AAV2/9 Vectors in Adult Mice Results in Efficient Transduction of the Retina
    Bemelmans, A.
    Duque, S.
    Riviere, C.
    Marais, T.
    Astord, S.
    Desrosiers, M.
    Sahel, J. -A.
    Volt, T.
    Barkats, M.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (13)
  • [47] Several Novel Adeno-Associated Virus (AAV) Capsids Show Unique Retinal Transduction by Intravitreal Delivery to Adult C57Bl/6 Mice
    Woodard, Kenton T.
    Murphy, Gabe J.
    Wimberly, Keon
    Kukielczak-Detweiler, Barbara M.
    Gray, Steven J.
    MOLECULAR THERAPY, 2017, 25 (05) : 255 - 256
  • [48] Development of the AAV6-Based Vectors With Selective Tropism and High Transduction Efficiency of Human Cancer Cells
    Sayroo, Rana
    Yin, Zifei
    Nalasco, Diego
    Pandya, Munjal
    Ling, Chen
    Ling, Changquan
    Aslanidi, George
    MOLECULAR THERAPY, 2015, 23 : S126 - S126
  • [49] Systemic gene transfer reveals distinctive muscle transduction profile of tyrosine mutant AAV-1,-6, and-9 in neonatal dogs
    Hakim, Chady H.
    Yue, Yongping
    Shin, Jin-Hong
    Williams, Regina R.
    Zhang, Keqing
    Smith, Bruce F.
    Duan, Dongsheng
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2014, 1 : 14002
  • [50] AAV9 transduction mediated by systemic delivery of vector via retro-orbital injection in newborn, neonatal and juvenile mice
    Prabhakar, Shilpa
    Lule, Sevda
    Da Hora, Cintia Carla
    Breakefield, Xandra O.
    Cheah, Pike See
    EXPERIMENTAL ANIMALS, 2021, 70 (04) : 450 - 458
12345