Increased risk of ischemic stroke in amyotrophic lateral sclerosis: a nationwide cohort study in South Korea

被引：0
作者：
Kwon, Soonwook [1 ]
Kim, Bongseong [2 ]
Han, Kyung-Do [2 ]
Jung, Wonyoung [3 ]
Cho, Eun Bin [4 ,5 ]
Shin, Dong Wook [6 ,7 ,13 ,14 ]
Min, Ju-Hong [8 ,9 ,10 ,11 ,12 ]
机构：
[1] Inha Univ, Inha Univ Hosp, Dept Neurol, Sch Med, Incheon 22332, South Korea
[2] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea
[3] Hallym Univ, Kangdong Sacred Heart Hosp, Dept Family Med, Seoul, South Korea
[4] Gyeongsang Natl Univ, Coll Med, Dept Neurol, Jinju 660702, South Korea
[5] Gyeongsang Natl Univ, Changwon Hosp, Dept Neurol, Changwon Si, Gyeongsangnam D, South Korea
[6] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Clin Res Design & Evaluat, Seoul, South Korea
[7] Sungkyunkwan Univ, Dept Family Med Support Care Ctr, Samsung Med Ctr, Sch Med, Seoul, South Korea
[8] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Sch Med, Seoul, South Korea
[9] Samsung Med Ctr, Neurosci Ctr, Seoul, South Korea
[10] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Seoul, South Korea
[11] Sungkyunkwan Univ, Neurosci Ctr, Samsung Med Ctr, Dept Neurol,Sch Med,Neurosci Ctr, Seoul, South Korea
[12] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, 50 Irwon dong, Seoul 06351, South Korea
[13] Sungkyunkwan Univ, Dept Family Med & Support Care Ctr, Samsung Med Ctr, Sch Med, Seoul, South Korea
[14] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Clin Res Design & Evaluat, Dept digital Hlth, 50 Irwon Dong, Seoul, South Korea
来源：
NEUROLOGICAL SCIENCES | 2025年
关键词：
Amyotrophic lateral sclerosis; Ischemic stroke; Physical disability; Epidemiology; South Korea; PROFILE; INFLAMMATION; INDEX;
D O I：
10.1007/s10072-025-08074-1
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background We investigated the risk of ischemic stroke in ALS and analyzed the effect of ALS-related physical disability using the Korean National Health Insurance Service database. Methods A total of 2,251 ALS patients diagnosed between January 1, 2012, and December 31, 2015, and 1:10 age- and sex-matched control populations were included. Cases that participated in the national health check-up programs were selected. A Cox hazard regression model was used to examine the hazard ratios (HRs) for ischemic stroke in ALS after adjusting for potential confounders. Results A total of 681 ALS patients and 10,934 non-ALS participants were selected. ALS patients were slightly younger than the control group (60.3 +/- 10.1 years vs. 61.0 +/- 10.5 years, p = 0.105), and the proportion of male patients was similar between the two groups (61.6% vs. 60.9%, p = 0.722). ALS patients were more likely to have a lower body mass index (23.1 +/- 2.92 vs. 24.0 +/- 3.1, p < 0.001) and obstructive sleep apnea syndrome (0.59% vs. 0.06%, p < 0.001) than the controls. In ALS patients, the incidence rate of ischemic stroke was 6.32 per 1,000 person-years, and the adjusted HR of ischemic stroke was 2.58 (95% confidence interval 1.38 - 4.82) compared with the matched group. The risk of ischemic stroke did not differ by the presence of disability in ALS patients. Conclusions Our findings suggest that ALS patients have an increased risk of ischemic stroke compared with controls, but the risk did not differ by the presence of disability in ALS.
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页码：2687 / 2695
页数：9
相关论文
共 39 条
  • [1] Feldman E.L., Goutman S.A., Petri S., Mazzini L., Savelieff M.G., Shaw P.J., Sobue G., Amyotrophic lateral sclerosis, Lancet, 400, pp. 1363-1380, (2022)
  • [2] Katsumata Y., Fardo D.W., Kukull W.A., Nelson P.T., Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer’s disease and cerebrovascular disease pathologies, Acta Neuropathol Commun, 6, 1, (2018)
  • [3] Huangfu N., Wang Y., Xu Z., Zheng W., Tao C., Li Z., Hu Y., Chen X., TDP43 exacerbates atherosclerosis progression by promoting inflammation and lipid uptake of macrophages, Front Cell Dev Biol, 9, (2021)
  • [4] Pereira M., Gromicho M., Henriques A., Pronto-Laborinho A.C., Grosskreutz J., Kuzma-Kozakiewicz M., Petri S., Uysal H., Swash M., de Carvalho M., Cardiovascular comorbidities in amyotrophic lateral sclerosis, J Neurol Sci, 421, (2021)
  • [5] Diekmann K., Kuzma-Kozakiewicz M., Piotrkiewicz M., Gromicho M., Grosskreutz J., Andersen P.M., de Carvalho M., Uysal H., Osmanovic A., Schreiber-Katz O., Petri S., Korner S., Impact of comorbidities and co-medication on disease onset and progression in a large German ALS patient group, J Neurol, 267, 7, pp. 2130-2141, (2020)
  • [6] Turner M.R., Goldacre R., Talbot K., Goldacre M.J., Cerebrovascular injury as a risk factor for amyotrophic lateral sclerosis, J Neurol Neurosurg Psychiatry, 87, 3, pp. 244-246, (2016)
  • [7] Shin D.W., Cho B., Guallar E., Korean National health insurance database, JAMA Intern Med, 176, 1, (2016)
  • [8] Cheol Seong S., Kim Y.Y., Khang Y.H., Heon Park J., Kang H.J., Lee H., Do C.H., Song J.S., Hyon Bang J., Ha S., Lee E.J., Ae Shin S., Data resource profile: the National health information database of the National health insurance service in South Korea, Int J Epidemiol, 46, 3, pp. 799-800, (2017)
  • [9] Shin D.W., Cho J., Park J.H., Cho B., National general health screening program in Korea: history, current status, and future direction, Precis Future Med, 6, 1, pp. 9-31, (2022)
  • [10] Kwon S., Kim B., Han K.D., Jung W., Cho E.B., Shin D.W., Min J.H., Risk of depression in amyotrophic lateral sclerosis: A nationwide cohort study in South Korea, J Psychiatr Res, 178, pp. 414-420, (2024)
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