Proteogenomic profiling of acute myeloid leukemia to identify therapeutic targets

被引:0
作者
Murray, Heather C. [1 ,2 ]
Sillar, Jonathan [1 ,2 ,3 ]
Chambers, Maddison [1 ,2 ]
Verrills, Nicole M. [1 ,2 ]
机构
[1] Univ Newcastle, Coll Hlth Med & Wellbeing, Sch Biomed Sci & Pharm, Callaghan, NSW, Australia
[2] Hunter Med Res Inst, Precis Med Res Program, New Lambton Hts, NSW, Australia
[3] Calvary Mater Hosp, Dept Haematol, Waratah, NSW, Australia
关键词
Acute myeloid leukemia; biomarkers; phosphoproteomics; precision therapy; proteogenomics; proteomics; ACUTE PROMYELOCYTIC LEUKEMIA; SET ENRICHMENT ANALYSIS; CLONAL HEMATOPOIESIS; RETINOIC ACID; PHOSPHOPROTEOME ANALYSIS; ARSENIC TRIOXIDE; FLT3; INHIBITORS; ADULT PATIENTS; AML; 10; PROTEOMICS;
D O I
10.1080/14789450.2024.2431272
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Introduction: Acute myeloid leukemia (AML) is an aggressive and poor-prognosis blood cancer. Despite a low mutation burden compared to other cancers, AML is heterogenous and identifying robust therapeutic targets has been difficult. Genomic profiling has greatly advanced our understanding of AML, and has revealed targets for AML therapy. However, only 50% of AML patients have gene mutations that are currently druggable, and relapse rates remain high. The addition of proteomic profiling is emerging to address these challenges. Areas covered: Using references collected through Pubmed, we review recent studies that have combined genomic and proteomic profiling (i.e. proteogenomic profiling), as well as studies that have additionally integrated other omics approaches, such as phosphoproteomics. We highlight how proteogenomic profiling promises to deconvolve the cellular pathways driving leukemogenesis, uncover novel therapeutic targets, and identify biomarkers of response to novel and existing therapies. Expert opinion: Proteogenomic profiling is providing unparalleled insight into AML, and is beginning to identify robust biomarkers. Standardization of workflows will be required before mass spectrometry-based proteomic assays can be integrated into routine clinical use. However, the demonstrated ability to adapt signatures into biomarker panels that can be assayed by existing clinical workflows is enabling current clinical translation.
引用
收藏
页码:515 / 528
页数:14
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