Interplay between miRNA expression and glucose metabolism in oral squamous cell carcinoma

Objective: Given the urgent need for improved diagnostic and therapeutic strategies in oral squamous cell carcinoma (OSCC), this review aims to explore the intricate interplay between OSCC and alterations in glucose metabolism, with a particular focus on the pivotal role of microRNAs (miRNAs) in this context. Material and methods: Data were extracted from a vast literature survey by using PubMed, Embase, and Web of Science search engines with relevant keywords. Results: In OSCC, miRNAs exert regulatory control over the expression of genes involved in glucose metabolism pathways. Dysregulation of specific miRNAs has been implicated in the modulation of key glycolytic enzymes and glucose transporters, intracellular signaling cascades, and interaction with transcription factors, all of which collectively affect glucose uptake and glycolysis, contributing significantly to the observed metabolic alterations in OSCC cells. Conclusion: A comprehensive understanding of these intricate molecular interactions holds significant promise for the development of targeted therapeutic interventions and refined diagnostic approaches to treat OSCC patients.