Early Mortality Stratification with Serum Albumin and the Sequential Organ Failure Assessment Score at Emergency Department Admission in Septic Shock Patients

被引:0
|
作者
Kim, Sang-Min [1 ]
Ryoo, Seung-Mok [1 ]
Shin, Tae-Gun [2 ]
Jo, You-Hwan [3 ]
Kim, Kyuseok [4 ]
Lim, Tae-Ho [5 ]
Chung, Sung-Phil [6 ]
Choi, Sung-Hyuk [7 ]
Suh, Gil-Joon [8 ]
Kim, Won-Young [1 ]
机构
[1] Univ Ulsan, Dept Emergency Med, Coll Med, Asan Med Ctr, Seoul 05505, South Korea
[2] Sungkyunkwan Univ, Sch Med, Dept Emergency Med, Samsung Med Ctr, Seoul 06351, South Korea
[3] Seoul Natl Univ, Coll Med, Dept Emergency Med, Bundang Hosp, Seongnam 13620, South Korea
[4] CHA Univ, CHA Bundang Med Ctr, Dept Emergency Med, Seongnam 13497, South Korea
[5] Hanyang Univ, Coll Med, Dept Emergency Med, Seoul 04763, South Korea
[6] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Emergency Med, Seoul 06273, South Korea
[7] Korea Univ, Guro Hosp, Coll Med, Dept Emergency Med, Seoul 08308, South Korea
[8] Seoul Natl Univ Hosp, Dept Emergency Med, Seoul 03080, South Korea
来源
LIFE-BASEL | 2024年 / 14卷 / 10期
关键词
septic shock; SOFA score; albumin; prognosis; risk stratification; INTERNATIONAL CONSENSUS DEFINITIONS; GOAL-DIRECTED RESUSCITATION; NUTRITIONAL-STATUS; SOFA SCORE; LONG-TERM; SEPSIS; ASSOCIATION; INFECTION; CRITERIA;
D O I
10.3390/life14101257
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Early risk stratification is crucial due to septic patients' heterogeneity. Serum albumin level may reflect the severity of sepsis and host status. This study aimed to evaluate the prognostic ability of the initial sequential organ failure assessment (SOFA) score alone and combined with serum albumin levels for predicting 28-day mortality in patients with septic shock. Methods: We conducted an observational study using a prospective, multicenter registry of septic shock patients between October 2015 and May 2022 from 12 emergency departments in the Korean Shock Society and the results were validated by examining those from the septic shock cohort in Asan Medical Center. The primary outcome was 28-day mortality. The area under the receiver operating characteristic (ROC) curve was used to compare the predictive values of SOFA score alone and SOFA score combined with serum albumin level. Results: Among 5805 septic shock patients, 1529 (26.3%) died within 28 days. Mortality increased stepwise with decreasing serum albumin levels (13.6% in albumin >= 3.5, 20.7% in 3.5-3.0, 29.7% in 3.0-2.5, 44.0% in 2.5-2.0, 56.4% in <2.0). The albumin SOFA score was calculated by adding the initial SOFA score to the 4 points assigned for albumin levels. ROC analysis for predicting 28-day mortality showed that the area under the curve for the albumin SOFA score was 0.71 (95% CI 0.70-0.73), which was significantly higher than that of the initial SOFA score alone (0.68, 95% CI: 0.67-0.69). Conclusions: The combination of the initial SOFA score with albumin can improve prognostic accuracy for patients with septic shock, suggesting the albumin SOFA score may be used as an early mortality stratification tool.
引用
收藏
页数:13
相关论文
共 50 条
  • [31] Vitamin D deficiency on admission to the emergency department is a mortality predictor for patients with septic shock treated with early protocol-driven resuscitation bundle therapy
    Chae, Bora
    Kim, Youn-Jung
    Kim, Sang Min
    Hong, Seok-In
    Shin, Yo Sep
    Kim, June -Sung
    Ryoo, Seung Mok
    Kim, Won Young
    AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2023, 365 (04) : 361 - 367
  • [32] External validation of the MISSED score to predict mortality in patients with severe sepsis and septic shock in the emergency department
    Ryoo, Seung Mok
    Ahn, Shin
    Kim, Won Young
    Lim, Kyoung Soo
    EUROPEAN JOURNAL OF EMERGENCY MEDICINE, 2015, 22 (05) : 327 - 330
  • [33] EARLY INITIATION OF VASOPRESSIN REDUCES ORGAN FAILURE AND MORTALITY IN SEPTIC SHOCK
    Rydz, Alexandria C.
    Elefritz, Jessica L.
    Conroy, Megan
    Disney, Kathryn A.
    Miller, Christopher J.
    Porter, Kyle
    Doepker, Bruce A.
    SHOCK, 2022, 58 (04): : 269 - 274
  • [34] Validation of quick sequential organ failure assessment score for poor outcome prediction among emergency department patients with suspected infection
    Sohn, Young Wha
    Jang, Hye Young
    Park, Suyeon
    Lee, Youngjoo
    Cho, Young Shin
    Park, Junbum
    Chung, Heajin
    Kim, Sang-Il
    CLINICAL AND EXPERIMENTAL EMERGENCY MEDICINE, 2019, 6 (04): : 314 - 320
  • [35] Bioactive adrenomedullin in sepsis patients in the emergency department is associated with mortality, organ failure and admission to intensive care
    Lundberg, Oscar H. M.
    Rosenqvist, Mari
    Bronton, Kevin
    Schulte, Janin
    Friberg, Hans
    Melander, Olle
    PLOS ONE, 2022, 17 (04):
  • [36] Early Changes in the Sequential Organ Failure Assessment Score Among Patients With Sepsis-Induced Disseminated Intravascular Coagulation
    Mochizuki, Katsunori
    Mori, Kotaro
    Nakamura, Yuta
    Uchimido, Ryo
    Kamijo, Hiroshi
    Takeshige, Kanako
    Nitta, Kenichi
    Imamura, Hiroshi
    CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2018, 24 : 332S - 339S
  • [37] Quick Sepsis-related Organ Failure Assessment score is not sensitive enough to predict 28-day mortality in emergency department patients with sepsis: a retrospective review
    Kim, Kyung Su
    Suh, Gil Joon
    Kim, Kyuseok
    Kwon, Woon Yong
    Shin, Jonghwan
    Jo, You Hwan
    Lee, Jae Hyuk
    Lee, Huijai
    CLINICAL AND EXPERIMENTAL EMERGENCY MEDICINE, 2019, 6 (01): : 77 - 83
  • [38] Contribution of Quick Sequential Organ Failure Assessment Score Combined with Electrocardiography in Risk Stratification of Patients with Acute Pulmonary Embolism
    Teng, Fei
    Chen, Yun-Xia
    He, Xin-Hua
    Guo, Shu-Bin
    CHINESE MEDICAL JOURNAL, 2018, 131 (20) : 2395 - 2401
  • [39] The prognostic value of the lactate/albumin ratio for predicting mortality in septic patients presenting to the emergency department: a prospective study
    Bou Chebl, Ralphe
    Geha, Mirabelle
    Assaf, Mohamad
    Kattouf, Nadim
    Haidar, Saadeddine
    Abdeldaem, Karim
    Halawi, Nour
    Khamis, Mohamed
    Makki, Maha
    Tamim, Hani
    Abou Dagher, Gilbert
    ANNALS OF MEDICINE, 2021, 53 (01) : 2268 - 2277
  • [40] Mortality and Sequential Organ Failure Assessment Score in Patients With Suspected Sepsis: The Impact of Acute and Preexisting Organ Failures and Infection Likelihood
    Christensen, Erik E.
    Prebensen, Christian H.
    Martinsen, Anders B.
    Stiff, Elisabeth T.
    Hoff, Rune
    Kvale, Dag
    Holten, Aleksander R.
    CRITICAL CARE EXPLORATIONS, 2023, 5 (02) : E0865