Associations of chronic kidney disease with hidradenitis suppurativa: A bidirectional Mendelian randomization study

Observational studies have indicated an association between chronic kidney disease (CKD) and hidradenitis suppurativa (HS). Nevertheless, causality remains unclear. Bidirectional Mendelian randomization (MR) analyses were conducted to investigate the direction of association between CKD and HS. The inverse variance weighting analysis of random effects was used as the primary analytical method and verified through sensitivity analyses. The MR analysis revealed that CKD is associated with an increased risk of HS (odds ratio = 1.577 [95% confidence interval = 1.065-2.337], p = 0.023), and estimated glomerular filtration rate does not increase the risk of HS. In addition, reverse MR analyses revealed no significant associations between HS and CKD. This study provides evidence that CKD is a significant risk factor for HS. However, further research is needed to explore the association between CKD and HS.