First Detection of Antibodies Specific to Crimean-Congo Hemorrhagic Fever Virus in Rural Populations of Gabon

被引：2

作者：

Kombila, Linda Bohou ^{[1
,2
]}

Lerolle, Solene ^{[3
]}

Mombo, Illich Manfred ^{[1
]}

Longo-Pendy, Neil-Michel ^{[4
]}

Mavoungou, Danielle Koumba ^{[1
,2
]}

Maganga, Gael Darren ^{[1
,5
]}

Cosset, Francois-Loic ^{[3
]}

Vanhomwegen, Jessica ^{[6
]}

Deschermeier, Christina ^{[7
]}

Leroy, Eric Maurice ^{[8
]}

Legros, Vincent ^{[3
,9
]}

N'dilimabaka, Nadine ^{[1
,10
]}

Becquart, Pierre ^{[8
]}

机构：

[1] Ctr Interdisciplinaire Rech Med Franceville, Dept Virol, Unite Emergence Malad Virales, Franceville, Gabon

[2] Univ Sci & Tech Masuku, Ecole Doctorale Reg Afrique Cent Infect Trop, Franceville, Gabon

[3] Univ Claude Bernard Lyon 1, Univ Lyon, Ctr Int Rech Infectiol,Inst Natl Sante & Rech Med, Ctr Natl Rech Sci,Ecole Normale Super,UMR5308,U11, Lyon, France

[4] Ctr Interdisciplinaire Rech Med Franceville, Unite Rech Ecol Sant, Franceville, Gabon

[5] Univ Sci & Tech Masuku, Inst Natl Super Agron & Biotechnol, Franceville, Gabon

[6] Inst Pasteur Paris, Cellule Intervent Biol Urgence, Paris, France

[7] Panadea Diagnost GmbH, Hamburg, Germany

[8] Univ Montpellier, Inst Rech Dev, Ctr Natl Rech Sci, Malad Infect & Vecteurs Ecol Genet Evolut & Contr, F-34394 Montpellier, France

[9] Univ Lyon, Campus Vet Lyon, VetAgro Sup, Marcy Letoile, France

[10] Univ Sci & Tech Masuku, Fac Sci, Dept Biol, Franceville, Gabon

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2024年 / 111卷 / 04期

关键词：

TICKS; IDENTIFICATION; TRANSMISSION; MAINTENANCE; INFECTION; IXODIDAE;

D O I：

10.4269/ajtmh.24-0054

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease with a mortality rate reaching up to 40% in humans. Currently, CCHF affects three continents: Asia, Europe, and Africa. An increase in confirmed cases in Africa has been observed since 2000. In Central Africa, several countries have reported the circulation of CCHV virus (CCHFV). However, in Gabon, there is a lack of recent data on the circulation of the virus in the Gabonese population. To provide an overview of the epidemiological situation in Gabon, we tested 3,081 human serum samples collected between 2005 and 2008 in villages throughout the country for anti-CCHFV antibodies. Using a double-antigen ELISA kit, our study found 15/3,081 samples positive for CCHFV. These positive samples were also tested using the Blackbox CCHFV IgG kit and the Luminex technique. These analyses confirmed seven and four positives for the Blackbox CCHFV IgG kit and the Luminex technique, respectively. This study suggests low circulation of CCHFV in the rural human population of Gabon. Competent authorities must survey CCHFV to identify and prevent clinical cases in the human population.

引用

页码：880 / 886

页数：7

共 31 条

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