Itaconate promotes an unexpected tumor immune escape mechanism

被引：0
|
作者：
Haase, Lara [1 ,2 ]
Frezza, Christian [1 ,2 ,3 ]
机构：
[1] Univ Cologne, Fac Med, Inst Metabol Ageing, Cluster Excellence Cellular Stress Responses Aging, Cologne, Germany
[2] Univ Hosp Cologne, Cologne, Germany
[3] Univ Cologne, Inst Genet, Fac Math & Nat Sci, Cologne, Germany
来源：
CANCER CELL | 2024年 / 42卷 / 12期
关键词：
D O I：
10.1016/j.ccell.2024.10.011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Itaconate is a metabolite produced by macrophages upon infection and acts as an antimicrobial molecule. In this issue of Cancer Cell, Lin et al. find that itaconate produced by tumor-associated macrophages is taken up by cancer cells via the transporter solute carrier family 13 member 3 (SLC13A3), promoting resistance to immune checkpoint inhibitors.
引用
收藏
页码：1988 / 1990
页数：3
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