US multicenter outcomes of endoscopic ultrasound-guided gallbladder drainage with lumen-apposing metal stents for acute cholecystitis

被引:1
作者
David, Yakira [1 ]
Kakked, Gaurav [2 ]
Confer, Bradley [3 ]
Shah, Ruchit [4 ]
Khara, Harshit [4 ]
Diehl, David L. [3 ]
Krafft, Matthew RichardKrafft [5 ]
Shah-Khan, Sardar M. [6 ]
Nasr, John Y. [7 ]
Benias, Petros [8 ]
Trindad, Arvinde [9 ]
Muniraj, Thiruvengada [10 ]
Aslanian, Harry [11 ]
Chahal, Prabhleen [12 ]
Rodriguez, John [12 ]
Adler, Douglas G. [13 ]
Dubroff, Jason [14 ]
De Latour, Rabi [15 ]
Tzimas, Demetrios [16 ]
Khanna, Lauren [15 ]
Haber, Gregory [15 ]
Goodman, Adam J. [17 ]
Hoerter, Nicholas [18 ]
Pandey, Nishi [19 ]
Bakhit, Mena [20 ]
Kowalski, Thomas E. [21 ]
Loren, David [22 ]
Chiang, Austin [23 ]
Schlachterman, Alexander [24 ]
Nieto, Jose [25 ]
Deshmukh, Ameya [26 ]
Ichkhanian, Yervant [27 ]
Khashab, Mouen A. [28 ]
El Halabi, Maan [29 ]
Kwon, Richard S. [30 ]
Prabhu, Anoop [31 ]
Hernandez-Lara, Ariosto [32 ]
Storm, Andrew
Berzin, Tyler M. [33 ]
Ponero, John [34 ]
Sethi, Amrita [35 ]
Gonda, Tamas A. [36 ]
Kushnir, Vladimir [37 ]
Cosgrove, Natalie [38 ]
Mullady, Daniel
Al-Shahrani, Abdullah [39 ]
D'Souza, Lionel [40 ]
Buscaglia, Jonathan [41 ]
Bucobo, Juan Carlos [42 ]
Rolston, Vineet [43 ]
机构
[1] Mayo Clin, Coll Med & Sci, Rochester, MN USA
[2] Rush Univ, Med Ctr, Chicago, IL USA
[3] Geisinger Med Ctr, Gastroenterol & Nutr, Danville, PA USA
[4] Geisinger Med Ctr, Danville, PA USA
[5] Ruby Mem Hosp, Morgantown, WV 26506 USA
[6] Rutgers Robert Wood Johnson Med Sch, Gastroenterol, New Brunswick, NJ USA
[7] West Virginia Univ, Sch Med, Digest Dis, Morgantown, WV USA
[8] Rutgers State Univ, New Brunswick, NJ USA
[9] North Shore Long Isl Jewish Med Ctr, New Hyde Pk, NY USA
[10] Yale Univ, New Haven, CT USA
[11] Yale Univ, Sch Med, Dept Med, Sect Digest Dis, New Haven, CT USA
[12] Cleveland Clin, Cleveland, OH USA
[13] Univ Utah, Sch Med, Gastroenterol, Salt Lake City, UT 84112 USA
[14] Univ Utah Hlth, Salt Lake City, UT USA
[15] NYU Langone Hlth, New York, NY USA
[16] Northwell Hlth, New Hyde Pk, NY USA
[17] NYU, Langone Med Ctr, Gastroenterol, New York, NY USA
[18] Icahn Sch Med Mt Sinai, New York, NY USA
[19] Bayonne Med Ctr, Bayonne, NJ USA
[20] Brown Univ, Warren Alpert Med Sch, Providence, RI USA
[21] Thomas Jefferson Univ, Gastroenterol, Ctr City Campus, Philadelphia, PA USA
[22] Fox Chase Canc Ctr, Philadelphia, PA USA
[23] Thomas Jefferson Univ Hosp, JeffSTAT Educ Ctr, Philadelphia, PA 19107 USA
[24] Univ Florida, Div Gastroenterol Hepatol & Nutr, Gainesville, FL USA
[25] Borland Groover Clin, Gastroenterol, Jacksonville, FL USA
[26] ST LOUIS UNIV, St. Louis, MO USA
[27] Indiana Univ, Bloomington, IN 47405 USA
[28] Johns Hopkins Univ Hosp, Gastroenterol, Baltimore, MD USA
[29] Tufts Med Ctr, Boston, MA USA
[30] Univ Michigan, Internal Med, Ann Arbor, MI USA
[31] Roswell Pk Comprehens Canc Ctr, Buffalo, NY USA
[32] Mayo Fdn Med Educ & Res, Rochester, MN USA
[33] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Gastroenterol, Boston, MA USA
[34] Columbia Univ, Digest & Liver Dis, Med Ctr, New York, NY USA
[35] Columbia Presbyterian Med Ctr, New York, NY 10032 USA
[36] Columbia Univ, Digest & Liver Dis, Med Ctr, New York, NY USA
[37] Washington Univ St Louis, St Louis, MO USA
[38] Thomas Jefferson Univ, Gastroenterol & Hepatol, Philadelphia, PA 19107 USA
[39] CU Anschutz Med Campus, Aurora, CO USA
[40] Stony Brook Univ Hosp, Stony Brook, NY USA
[41] SUNY Stony Brook, Stony Brook, NY USA
[42] North Shore Univ Hosp, Manhasset, NY USA
[43] Mem Sloan Kettering Canc Ctr, New York, NY USA
[44] Methodist Dallas Med Ctr, Gastroenterol, Dallas, TX USA
[45] HCA Florida Aventura Hosp & Med Ctr, Aventura, FL USA
[46] Icahn Sch Med Mt Sinai, Med, New York, NY USA
[47] Icahn Sch Med Mt Sinai, Dr Henry D Janowitz Div Gastroenterol, New York, NY USA
[48] Catholic Hlth St Francis Hosp & Heart Ctr, Roslyn, NY USA
关键词
Endoscopic ultrasonography; Intervention EUS; Biliary tract; Quality and logistical aspects; Performance and complications; PERCUTANEOUS CHOLECYSTOSTOMY; ACALCULOUS CHOLECYSTITIS; STRATEGIES; MANAGEMENT;
D O I
10.1055/a-2495-5542
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background and study aims EUS-guided gallbladder drainage (EUS-GBD) using lumen apposing metal stents (LAMS) has excellent technical and short-term clinical success for acute cholecystitis (AC). The goals of this study were to determine the long-term clinical outcomes and adverse events (AEs) of EUS-GBD with LAMS. Patients and methods A multicenter, retrospective study was conducted at 18 US tertiary care institutions. Inclusion criteria: any AC patient with attempted EUS-GBD with LAMS and minimum 30-day post-procedure follow-up. Long-term clinical success was defined as absence of recurrent acute cholecystitis (RAC) > 30 days and long-term AE was defined as occurring > 30 days from the index procedure. Results A total of 109 patients were included. Technical success was achieved in 108 of 109 (99.1%) and initial clinical success in 106 of 109 (97.2%). Long-term clinical success was achieved in 98 of 109 (89.9%) over a median follow-up of 140 days (range 30-1188). On multivariable analysis (MVA), acalculous cholecystitis (odds ratio [OR] 15.93, 95% confidence interval [CI] 1.22-208.52, P = 0.04) and the occurrence of a LAMS-specific AE (OR 63.60, 95% CI 5.08-799.29, P <0.01) were associated with RAC. AEs occurred in 38 of 109 patients (34.9%) at any time, and in 10 of 109 (9.17%) > 30 days from the index procedure. Most long-term AEs (7 of 109; 6.42%) were LAMS-specific. No technical or clinical factors were associated with occurrence of AEs. LAMS were removed in 24 of 109 patients (22%). There was no difference in RAC or AEs whether LAMS was removed or not. Conclusions EUS-GBD with LAMS has a high rate of long-term clinical success and modest AE rates in patients with AC and is a reasonable destination therapy for high-risk surgical candidates.
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