Polypeptides from Sea Cucumber Acaudina molpadioides Ameliorate Glucolipid Metabolism Disorder and Reverse Gut Microbiota Dysbiosis in Type 2 Diabetic Rats

被引：2

作者：

Ye, Di ^{[1
]}

Pei, Dong ^{[2
,3
,4
]}

Ding, Fangfang ^{[1
]}

Zhao, Qianqian ^{[1
]}

Huang, Danfei ^{[1
]}

机构：

[1] Nanchang Univ, Key Lab Bioact Polysaccharides Jiangxi Prov, China Canada Joint Lab Food Sci & Technol Nanchang, State Key Lab Food Sci & Resources,Int Inst Food I, 235 Nanjing East Rd, Nanchang 330047, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Resource Chem & New Mat, Qingdao, Shandong, Peoples R China

[3] Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou, Gansu, Peoples R China

[4] Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou, Gansu, Peoples R China

来源：

JOURNAL OF AQUATIC FOOD PRODUCT TECHNOLOGY | 2024年 / 33卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Sea cucumber polypeptide; diabetes mellitus; blood glucose; insulin; low-value aquatic products; POLYSACCHARIDE; MELLITUS; OBESITY; DIET;

D O I：

10.1080/10498850.2024.2421373

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The therapeutic effects of polypeptides isolated from sea cucumber Acaudina molpadioides (AP) on the intestinal flora and glycolipid metabolic disturbance in high-fat diet/STZ-induced T2DM rats were investigated. The results showed that AP intervention notably ameliorated blood glucose, lipid levels, and pancreas injuries in T2DM rats. The diversity of intestinal microbial communities in T2DM rats was also enhanced by AP. Moreover, microbially derived short-chain fatty acids concentrations markedly improved in the feces of diabetic rats after AP treatment. These results suggest that AP played a protective role in T2DM rats by regulating glucose, lipid metabolism, and altering intestinal microbial.

引用

页码：714 / 733

页数：20

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