Trauma exposure as a risk factor of major depressive disorder: A matched case-control study

被引：0

作者：

Lai, Wenjian ^{[1
,2
,3
]}

Zhang, Huimin ^{[4
]}

Jiang, Yingchen ^{[1
,2
]}

Huang, Xinyu ^{[1
,2
]}

Liao, Yuhua ^{[4
]}

Hao, Jiejing ^{[1
,2
,4
]}

Liu, Yifen ^{[4
]}

Chen, Yan ^{[4
]}

Wang, Wanxin ^{[1
,2
]}

Guo, Lan ^{[1
,2
]}

Zhang, Wei-Hong ^{[3
,5
]}

Teopiz, Kayla M. ^{[6
]}

Mcintyre, Roger S. ^{[6
,7
,8
]}

Han, Xue ^{[4
]}

Lu, Ciyong ^{[1
,2
]}

机构：

[1] Sun Yat sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, 74 Zhongshan Rd 2, Guangzhou 510080, Peoples R China

[2] Guangdong Engn Technol Res Ctr Nutr Translat, Guangzhou 510080, Peoples R China

[3] Univ Ghent, Fac Med & Hlth Sci, Int Ctr Reprod Hlth ICRH, Dept Publ Hlth & Primary Care, Ghent, Belgium

[4] Shenzhen Nanshan Ctr Chron Dis Control, Dept Psychiat, Shenzhen 518054, Peoples R China

[5] Univ Libre Bruxelles ULB, Sch Publ Hlth, Brussels, Belgium

[6] Brain & Cognit Discovery Fdn, Toronto, ON, Canada

[7] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada

[8] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 2025年 / 182卷

基金：

中国国家自然科学基金;

关键词：

Major depressive disorder; Childhood trauma; Stressful life event; Depression severity; Risk factor; Prevention; STRESSFUL LIFE EVENTS; CHILDHOOD EXPERIENCES; ADULT DEPRESSION; HEALTH; MALTREATMENT; PREVALENCE; ONSET; QUESTIONNAIRE; RECURRENCE; ADVERSITY;

D O I：

10.1016/j.jpsychires.2025.01.028

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The association between childhood trauma (CT), stressful life events (SLE) and the onset and severity of major depressive disorder (MDD) has not been extensively studied. This study aimed to investigate the separate and combined association of CT and SLE with the onset and severity of MDD. A total of 503 patients with MDD and 503 controls were included. The diagnosis of MDD was assessed using the Mini-International Neuropsychiatric Interview (M.I.N.I.) by trained psychiatrists. Trauma exposure was assessed using the short form of Childhood Trauma Questionnaire (CTQ-SF) and stressful life events screening questionnaire (SLESQ). A series of conditional logistic regression models and multiple linear regression models were performed. The majority of patients with MDD (84.9%) and controls (61.6%) have reported trauma exposure. After adjusting for covariates, exposure to CT or SLE was independently associated with an elevated risk of the onset and severity of MDD. Moreover, a significant additive interaction between CT and SLE on the onset of MDD was observed (relative excess risk due to interactions [RERI] = 6.93, 95% confidence interval [CI] = 0.19-13.66). MDD patients were more likely to experience both CT and SLE compared with controls (odds ratio [OR] = 10.37, 95% CI = 4.99-21.56). MDD patients with both CT and SLE experience were more like to have more severe depressive symptoms (beta = 2.16, 95% CI = 1.02-3.30). These findings underscore the importance of targeted prevention measures addressing the occurrence of CT and SLE to mitigate the risk of MDD development and the severity of depressive symptoms.

引用

页码：204 / 211

页数：8

共 52 条

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