Swermilactones A and B: racemic xanthone-secoiridoid heterodimers from Swertia mileensis

被引：0

作者：

Du, Yao ^{[1
,2
]}

Li, Hao ^{[1
,2
]}

Qi, Xiao-Yu ^{[1
,2
]}

Xu, Yuan-Liang ^{[1
,2
]}

Liu, Yan ^{[1
,2
]}

Niu, Xue-Mei ^{[1
,2
,3
,4
]}

Guo, Kai ^{[1
,2
]}

Li, Sheng-Hong ^{[1
,2
,5
,6
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China

[3] Yunnan Univ, State Key Lab Conservat & Utilizat Bioresources, Sch Life Sci, Kunming 650091, Peoples R China

[4] Yunnan Univ, Key Lab Microbial Resources, Sch Life Sci, Minist Educ, Kunming 650091, Peoples R China

[5] Chinese Acad Sci, State Key Lab Phytochem & Nat Med, Kunming 650201, Peoples R China

[6] Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1039/d5ob00326a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two pairs of racemic xanthone-secoiridoid heterodimers, (+/-)-swermilactones A (1) and B (2), were isolated from the whole plants of Swertia mileensis. Their structures, featuring an unusual C-C bond linkage between the xanthone and secoiridoid moieties, were elucidated by extensive spectroscopic analysis and ECD calculations. Compounds (+)-1, (-)-1, (+)-2, and (-)-2 moderately inhibited the secretion of cytokines TNF-alpha and IL-6 in LPS-induced RAW 264.7 macrophages with IC50 values ranging from 12.01 to 39.06 mu M.

引用

页数：5

共 13 条

[11] Swerpunilactones A and B, the first example of xanthone and secoiridoid heterodimers from Swertia punicea, S. hispidicalyx, and S. yunnanensis
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[13] Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis
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