Swermilactones A and B: racemic xanthone-secoiridoid heterodimers from Swertia mileensis

被引：0
作者：
Du, Yao [1 ,2 ]
Li, Hao [1 ,2 ]
Qi, Xiao-Yu [1 ,2 ]
Xu, Yuan-Liang [1 ,2 ]
Liu, Yan [1 ,2 ]
Niu, Xue-Mei [1 ,2 ,3 ,4 ]
Guo, Kai [1 ,2 ]
Li, Sheng-Hong [1 ,2 ,5 ,6 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China
[3] Yunnan Univ, State Key Lab Conservat & Utilizat Bioresources, Sch Life Sci, Kunming 650091, Peoples R China
[4] Yunnan Univ, Key Lab Microbial Resources, Sch Life Sci, Minist Educ, Kunming 650091, Peoples R China
[5] Chinese Acad Sci, State Key Lab Phytochem & Nat Med, Kunming 650201, Peoples R China
[6] Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1039/d5ob00326a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two pairs of racemic xanthone-secoiridoid heterodimers, (+/-)-swermilactones A (1) and B (2), were isolated from the whole plants of Swertia mileensis. Their structures, featuring an unusual C-C bond linkage between the xanthone and secoiridoid moieties, were elucidated by extensive spectroscopic analysis and ECD calculations. Compounds (+)-1, (-)-1, (+)-2, and (-)-2 moderately inhibited the secretion of cytokines TNF-alpha and IL-6 in LPS-induced RAW 264.7 macrophages with IC50 values ranging from 12.01 to 39.06 mu M.
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页数：5
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