Polycyclic Polyprenylated Acylphloroglucinols (PPAPs) from Garcinia Oblongifolia and their Antitumor Activity

被引：0
作者：
Yang, Si-Yu [3 ]
Lin, Qiang [1 ,2 ]
Zhuo, Xue-Fang [4 ]
Huang, Yue-Hao [1 ,2 ]
Wu, Wei [1 ,2 ]
Wu, Tian-Yuan [1 ,2 ]
Zheng, Wei-Xuan [1 ,2 ]
Li, Yao-Lan [1 ,2 ]
Wang, Guo-Cai [1 ,2 ]
Zhang, Yu-Bo [1 ,2 ,3 ]
机构：
[1] Jinan Univ, Coll Pharm, State Key Lab Bioact Mol & Druggabil Assessment, Guangzhou 510632, Peoples R China
[2] Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Peoples R China
[3] Jinan Univ, Guangdong Clin Translat Ctr Targeted Drug, Sch Med, Dept Pharmacol, Guangzhou 510632, Peoples R China
[4] Longgang Cent Hosp Shenzhen, Shenzhen, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2025年 / 22卷 / 03期
基金：
中国国家自然科学基金;
关键词：
<italic>Garcinia oblongifolia</italic>; Polycyclic polyprenylated acylphloroglucinols; Antitumor activity; BENZOYLPHLOROGLUCINOL DERIVATIVES;
D O I：
10.1002/cbdv.202402175
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new polycyclic polyprenylated acylphloroglucinols, along with four previously known compounds, were isolated and identified from the fruits of Garcinia oblongifolia. The structures of these compounds were elucidated through a combination of spectroscopic techniques, including MS, UV, IR, and 1D/2D NMR, as well as their chemical properties. Additionally, the cytotoxic activities of compounds 1-6 against the H134B cell line were evaluated using the MTT assay, revealing that compounds 1 and 2 exhibit promising antitumor activity.
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页数：5
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