Prevalence of mixed neuropathologies in age-related neurodegenerative diseases: A community-based autopsy study in China

被引：3

作者：

Wang, Xiaoxi ^{[1
]}

Zhu, Keqing ^{[2
,5
,6
]}

Wu, Wei ^{[3
,4
,7
]}

Zhou, Dan ^{[8
,9
]}

Lu, Hui ^{[10
]}

Du, Juan ^{[11
]}

Cai, Li ^{[12
]}

Yan, Xiaoxin ^{[13
]}

Li, Wensheng ^{[10
]}

Qian, Xiaojing ^{[3
,4
,7
]}

Wang, Xue ^{[3
,4
,7
]}

Ma, Chao ^{[3
,4
,7
]}

Hu, Yuting ^{[2
,14
]}

Tian, Chen ^{[1
]}

Sun, Bing ^{[2
,15
]}

Fang, Zheng ^{[2
,5
,6
]}

Wu, Juanli ^{[2
,15
]}

Jiang, Peiran ^{[2
,5
,6
]}

Liu, Jianxin ^{[2
]}

Liu, Cuiyun ^{[2
,15
]}

Fan, Jiayao ^{[8
,9
]}

Cui, Huixian ^{[11
]}

Shen, Yi ^{[2
,16
,17
]}

Duan, Shumin ^{[2
,5
,6
,18
,19
]}

Bao, Aimin ^{[2
,5
,6
,18
,20
]}

Yang, Ying ^{[1
]}

Qiu, Wenying ^{[3
,4
,7
]}

Zhang, Jing ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Pathol, Hangzhou, Peoples R China

[2] Zhejiang Univ, Sch Med, Natl Hlth & Dis Human Brain Tissue Resource Ctr, Hangzhou, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurobiol, Hangzhou, Peoples R China

[4] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurol, Hangzhou, Peoples R China

[5] Natl Human Brain Bank Dev, Inst Basic Med Sci, Neurosci Ctr, Beijing, Peoples R China

[6] Acad Med Sci, Beijing, Peoples R China

[7] Peking Union Med Coll, Sch Basic Med, Dept Human Anat Histol & Embryol, Beijing, Peoples R China

[8] Zhejiang Univ, Sch Publ Hlth, Sch Med, Hangzhou, Peoples R China

[9] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Peoples R China

[10] Fudan Univ, Sch Basic Med Sci, Dept Human Anat & Histoembryol, Fudan Branch,Natl Hlth & Dis Human Brain Tissue Re, Shanghai, Peoples R China

[11] Hebei Med Univ, Dept Human Anat, Human Brain Bank, Shijiazhuang, Peoples R China

[12] Anhui Med Univ, Sch Basic Med, Dept Pathol, Hefei, Peoples R China

[13] Cent South Univ, Xiangya Sch Med, Dept Anat & Neurobiol, Changsha, Peoples R China

[14] Zhejiang Univ, Affiliated Hosp 2, Ctr Basic & Translat Res, Sch Med, Hangzhou, Peoples R China

[15] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Mental Hlth, Hangzhou, Peoples R China

[16] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurobiol, Hangzhou, Peoples R China

[17] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou, Peoples R China

[18] Zhejiang Univ, MOE Frontier Sci Ctr Brain Res & Brain Machine Int, Sch Brain Sci & Brain Med, NHC & CAMS Key Lab Med Neurobiol, Hangzhou, Peoples R China

[19] Chinese Acad Med Sci, Res Units Emot & Emot Disorders, Hangzhou, Peoples R China

[20] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Orthoped, Hangzhou, Peoples R China

来源：

ALZHEIMERS & DEMENTIA | 2025年 / 21卷 / 01期

基金：

中国国家自然科学基金;

关键词：

aging-related tau astrogliopathy; Alzheimer's disease neuropathological change; cerebrovascular disease; Lewy body disease; limbic-predominant age-related TDP-43 encephalopathy; mixed neuropathology; primary age-related tauopathy; COGNITIVE IMPAIRMENT; ALZHEIMER; PATHOLOGY; GUIDELINES; DISORDER; BRAIN;

D O I：

10.1002/alz.14369

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: Despite extensive studies on mixed neuropathologies, data from China are limited. This study aims to fill this gap by analyzing brain samples from Chinese brain banks. METHODS: A total of 1142 brains from six Chinese brain banks were examined using standardized methods. Independent pathologists conducted evaluations with stringent quality control. Prevalence and correlations of neurological disorders were analyzed. RESULTS: Significant proportions of brains displayed primary age-related tauopathy (PART, 35%), limbic-predominant age-related TDP-43 encephalopathy (LATE, 46%), and aging-related tau astrogliopathy (ARTAG, 12%). Alzheimer's disease neuropathological change (ADNC, 48%), Lewy body disease (LBD, 13%), and cerebrovascular disease (CVD, 63%) were also prevalent, often co-occurring with regional variations. CVD emerged as the potential most early contributor to neuropathological changes. DISCUSSION: This analysis highlights the prevalence of PART, LATE, ARTAG, ADNC, LBD, and CVD, with regional differences. The findings suggest CVD may be the earliest contributing factor, potentially preceding other neuropathologies.

引用

页数：11

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