Dietary and nutritional interventions for human diseases: their modulatory effects on ferroptosis

被引:0
|
作者
Huang, Shiqiong [1 ]
Sun, Ji [1 ]
Shen, Chaozan [2 ]
He, Gefei [1 ]
机构
[1] Cent South Univ, Affiliated Changsha Hosp, Xiangya Sch Med, Changsha 410000, Peoples R China
[2] Second Peoples Hosp Huaihua, Dept Clin Pharm, Huaihua 418000, Peoples R China
关键词
PROMOTES FERROPTOSIS; CANCER; MICE; METABOLISM; ACTIVATION; MITOPHAGY; FERRITIN; INJURY; ROLES; CELLS;
D O I
10.1039/d4fo05606j
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A balanced diet is essential for maintaining human health. Increasing evidence suggests that dietary and nutritional interventions contribute to disease management and are associated with reduced healthcare costs and economic burden. Ferroptosis, a novel type of regulated cell death (RCD) driven by lipid peroxidation, has been shown to be involved in various pathological conditions, including diabetes, ischemia/reperfusion (I/R) injury, inflammation-related diseases, and cancer. Therefore, specifically targeting the uncontrolled ferroptosis process may offer new therapeutic opportunities. Of note, certain interventions, such as small-molecule compounds, natural products, herbal medicines, and non-pharmacological approaches, have been reported to prevent and treat multiple human diseases by reversing the dysregulation of ferroptosis. In this review, we present the key molecular mechanisms that regulate ferroptosis. Importantly, interventions targeting ferroptosis are summarized from the perspective of dietary patterns, food and nutrients. By understanding these advances, innovative ideas can be provided for individualized dietary interventions and treatment strategies.
引用
收藏
页码:1186 / 1204
页数:19
相关论文
共 50 条
  • [21] NUTRITION IN PREGNANCY - THE EFFECTS OF DIETARY DEFICIENCY IN PREGNANCY AND THE DETECTION AND TREATMENT OF NUTRITIONAL DEFICIENCY DISEASES
    VILTER, CF
    MORGAN, D
    SPIES, TD
    SURGERY GYNECOLOGY & OBSTETRICS, 1946, 83 (05): : 561 - +
  • [22] Ferroptosis and Its Potential Role in Human Diseases
    Han, Chu
    Liu, Yuanyuan
    Dai, Rongji
    Ismail, Nafissa
    Su, Weijun
    Li, Bo
    FRONTIERS IN PHARMACOLOGY, 2020, 11
  • [23] Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes (vol 171, pg 190, 2019)
    Khan, S. U.
    Khan, M. U.
    Riaz, H.
    ANNALS OF INTERNAL MEDICINE, 2020, 172 (01) : 75 - 76
  • [24] Human food choice and nutritional interventions
    Chadwick, P. M.
    Crawford, C.
    Ly, L.
    NUTRITION BULLETIN, 2013, 38 (01) : 36 - 42
  • [25] Nutritional interventions based on dietary restriction and nutrient reductions for the prevention of doxorubicin chemotherapy side effects
    Romero-Marquez, Jose M.
    Badillo-Carrasco, Alberto
    Navarro-Hortal, Maria D.
    Rivas-Garcia, Lorenzo
    Jimenez-Trigo, Victoria
    Varela-Lopez, Alfonso
    MEDITERRANEAN JOURNAL OF NUTRITION AND METABOLISM, 2021, 14 (04) : 427 - 438
  • [26] Nutritional interventions in aging and age-associated diseases
    Roth, George S.
    Ingram, Donald K.
    Joseph, James A.
    HEALTHY AGING AND LONGEVITY, 2007, 1114 : 369 - 371
  • [27] Molecular mechanisms underlying the beneficial effects of exercise and dietary interventions in the prevention of cardiometabolic diseases
    Forte, Maurizio
    Rodolico, Daniele
    Ameri, Pietro
    Catalucci, Daniele
    Chimenti, Cristina
    Crotti, Lia
    Schirone, Leonardo
    Pingitore, Annachiara
    Torella, Daniele
    Iacovone, Giuliano
    Valenti, Valentina
    Schiattarella, Gabriele
    Perrino, Cinzia
    Sciarretta, Sebastiano
    JOURNAL OF CARDIOVASCULAR MEDICINE, 2023, 24 : E3 - E14
  • [28] Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases
    Tian, Lei
    Zhao, Ruixiang
    Xu, Xinyi
    Zhou, Zhiwei
    Xu, Xiaofang
    Luo, Dongmei
    Zhou, Zhiqiang
    Liu, Yu
    Kushmaro, Ariel
    Marks, Robert S.
    Dinnyes, Andras
    Sun, Qun
    FOOD SCIENCE AND HUMAN WELLNESS, 2023, 12 (04) : 959 - 974
  • [29] Aged brain and neuroimmune responses to COVID-19: post-acute sequelae and modulatory effects of behavioral and nutritional interventions
    Mueller, Ludmila
    Di Benedetto, Svetlana
    IMMUNITY & AGEING, 2023, 20 (01)
  • [30] Aged brain and neuroimmune responses to COVID-19: post-acute sequelae and modulatory effects of behavioral and nutritional interventions
    Ludmila Müller
    Svetlana Di Benedetto
    Immunity & Ageing, 20