Exercise interventions to improve physical frailty and physical frailty components in older adults with hypertension: A systematic review

Physical frailty and hypertension are both highly prevalent among older adults. Furthermore, physical frailty may impact the risk-benefit ratio of pharmacological hypertension treatment. Thus, it may be prudent to focus on physical activity and exercise interventions to achieve better patient outcomes that addresses both conditions. This systematic review aimed to investigate the effects of exercise interventions on physical frailty components and hypertension-related outcomes in older adults with hypertension. PubMed/Medline, Embase, Cochrane Library, Cinahl and PEDro were searched for exercise trials in older adults with hypertension, measuring physical frailty or physical frailty components. Preferred Reporting Items for Systematic Review and Meta-Analysis protocol (PRISMA-P) and Physiotherapy Evidence Database (PEDro) scale were used for internal validity. The searches retrieved 4965 titles without duplicates. Ninety-four potential full texts were evaluated, and 30 original studies were included in the review. Mean methodological quality of the included studies was 5.7 out of 10. Only one study measured frailty (using a cumulative deficit model) in older adults with hypertension. Different types of exercise training demonstrated improvements in components of physical frailty. This systematic review shows that there is no evidence whether exercise ameliorates the effects of physical frailty and hypertension and there is a need for more data to be generated.