Impact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery: A Randomized Controlled Trial

被引:0
作者
Karkle, Aleksandra [1 ,2 ]
Neimane, Laura [1 ,2 ]
Zolovs, Maksims [3 ,4 ]
Dambergs, Matiss [2 ,5 ]
Meistere, Dita [1 ,2 ]
Vaskevica, Anete [1 ,2 ]
Slaidina, Anda [2 ,6 ]
机构
[1] Riga Stradins Univ, Dept Conservat Dent & Oral Hlth, LV-1007 Riga, Latvia
[2] RSU Inst Stomatol, LV-1007 Riga, Latvia
[3] Riga Stradins Univ, Stat Unit, LV-1007 Riga, Latvia
[4] Daugavpils Univ, Inst Life Sci & Technol, LV-5401 Daugavpils, Latvia
[5] Riga Stradins Univ, Dept Orthodont, LV-1007 Riga, Latvia
[6] Riga Stradins Univ, Dept Prosthet Dent, LV-1007 Riga, Latvia
关键词
apical surgery; advanced platelet-rich fibrin; bone regeneration; CBCT; APICOMARGINAL DEFECTS; SURGERY; MEMBRANE; DENSITY; PLASMA; RISK; 2D; CT;
D O I
10.3390/diagnostics15050516
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Apical surgery can address periapical pathologies when conventional endodontic treatments fail. Advanced platelet-rich fibrin (A-PRF) has emerged as a regenerative material with the potential to enhance healing in periapical surgery. In this study, we evaluated the effect of A-PRF on periapical lesion healing using cone beam computed tomography (CBCT). Methods: A randomized controlled trial at R & imacr;ga Stradi & ncedil;s University Institute of Stomatology included 43 participants (15 males, 28 females; mean age: 44 years) with periradicular lesions. Participants were divided into experimental and control groups. Baseline and follow-up CBCT imaging assessed lesion volumes at 6 and 12 months post-surgery. Results: Mean lesion volumes significantly decreased from 431.4 mm(3) at baseline to 102.8 mm(3) at 6 months and 49.2 mm(3) at 12 months (p < 0.001). A-PRF did not significantly reduce the lesion sizes compared to the controls (p = 0.043), but was associated with reduced inflammation and enhanced soft tissue healing. Key confounders included gender and baseline lesion volume, with males exhibiting smaller lesion sizes postoperatively. Conclusions: The results suggest that A-PRF may not offer a significant advantage in terms of reducing defect size or improving radiographic resolution.
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页数:17
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