C-H Functionalization of Quinoxalines

As a powerful tool in modern organic synthesis, C-H functionalization offers an elegant shortcut to molecular complexity, enabling direct bond transformations without any pre-functionalization. In this connection, the C-H functionalization of quinoxalines offers a di-rect and efficient approach to modify the quinoxaline scaffold, a keystructural motif in biologically active compounds and materials. This personal account describes the methodologies developed by our group for the C-H activation and functionalization of quinoxaline compounds. 1 Introduction 2 Difluoroalkylamidation 3 ortho C-H Alkylation 4 ortho C-H Amination 5 Conclusion