The sentinels of coronary artery disease: heterogeneous monocytes

被引:0
作者
Chen, Yanyu [1 ,2 ]
Luo, Daya [3 ]
Gao, Renzhuo [4 ]
Wu, Jinjing [3 ]
Qiu, Xingpeng [5 ]
Zou, Yang [1 ]
Jian, Yingchao [6 ]
Zhang, Shuhua [1 ]
机构
[1] Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Jiangxi Cardiovasc Res Inst, Nanchang, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China
[3] Nanchang Univ, Jiangxi Med Coll, Sch Basic Med Sci, Nanchang, Peoples R China
[4] Nanchang Univ, Queen Mary Coll, Sch Med, Nanchang, Peoples R China
[5] Nanchang Univ, Sch Basic Med Sci, Nanchang, Peoples R China
[6] Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Dept Radiol, Nanchang, Peoples R China
基金
中国国家自然科学基金;
关键词
monocyte heterogeneity; atherosclerosis; inflammation; coronary artery disease; flow cytometry; ACUTE MYOCARDIAL-INFARCTION; ST-ELEVATION; VULNERABILITY CHARACTERISTICS; NONCLASSICAL MONOCYTES; DENSITY-LIPOPROTEIN; GLUCOSE FLUCTUATION; FLOW RESERVE; RECEPTOR; SUBSETS; ASSOCIATION;
D O I
10.3389/fimmu.2025.1428978
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Monocytes are heterogeneous immune cells that play a crucial role in the inflammatory response during atherosclerosis, influencing the progression and outcome of the disease. In the pathogenesis of atherosclerotic diseases, such as coronary artery disease (CAD), monocytes not only serve as the initial sensors of endogenous and exogenous pathogenic factors, but also function as intermediators that bridge the circulatory system and localized lesions. In the bloodstream, heterogeneous monocytes, acting as sentinels, are rapidly recruited to atherosclerotic lesions, where they exhibit a heightened capacity to respond to various pathological stimuli upon detecting signals from damaged vascular endothelial cells. Clinical studies have demonstrated that the heterogeneity of monocytes in CAD patients presents both diversity and complexity, varying across different disease subtypes and pathological stages. This review explores the heterogeneity of monocytes in CAD, focusing on alterations in monocyte subset numbers, proportions, and the expression of functional receptors, as well as their correlations with clinical features. Additionally, we propose strategies to enhance the clinical utility value of monocyte heterogeneity and outline future research directions in the field of CAD. With the widespread application of high-parameter flow cytometry and single-cell sequencing technologies, it is anticipated that a comprehensive understanding of monocyte heterogeneity in CAD will be achieved, enabling the identification of disease-specific monocyte subtypes. This could offer new opportunities for improving the diagnosis and treatment of CAD.
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页数:15
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共 86 条
[51]   Pravastatin reverses the membrane cholesterol reorganization induced by myocardial infarction within lipid rafts in CD14+/CD16- circulating monocytes [J].
Salvary, Thomas ;
Gambert-Nicot, Segolene ;
Brindisi, Marie-Claude ;
Meneveau, Nicolas ;
Schiele, Francois ;
Seronde, Marie-France ;
Lorgis, Luc ;
Zeller, Marianne ;
Cottin, Yves ;
Kantelip, Jean-Pierre ;
Gambert, Philippe ;
Davani, Siamak .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2012, 1821 (09) :1287-1294
[52]   Monocyte Subsets: Phenotypes and Function in Tuberculosis Infection [J].
Sampath, Pavithra ;
Moideen, Kadar ;
Ranganathan, Uma Devi ;
Bethunaickan, Ramalingam .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[53]   S100A8 and S100A9: DAMPs at the Crossroads between Innate Immunity, Traditional Risk Factors, and Cardiovascular Disease [J].
Schiopu, Alexandru ;
Cotoi, Ovidiu S. .
MEDIATORS OF INFLAMMATION, 2013, 2013
[54]   Transcription and enhancer profiling in human monocyte subsets [J].
Schmidl, Christian ;
Renner, Kathrin ;
Peter, Katrin ;
Eder, Ruediger ;
Lassmann, Timo ;
Balwierz, Piotr J. ;
Itoh, Masayoshi ;
Nagao-Sato, Sayaka ;
Kawaji, Hideya ;
Carninci, Piero ;
Suzuki, Harukazu ;
Hayashizaki, Yoshihide ;
Andreesen, Reinhard ;
Hume, David A. ;
Hoffmann, Petra ;
Forrest, Alistair R. R. ;
Kreutz, Marina P. ;
Edinger, Matthias ;
Rehli, Michael .
BLOOD, 2014, 123 (17) :E90-E99
[55]   Innate immunity and monocyte-macrophage activation in atherosclerosis [J].
Shalhoub, Joseph ;
Falck-Hansen, Mika A. ;
Davies, Alun H. ;
Monaco, Claudia .
JOURNAL OF INFLAMMATION-LONDON, 2011, 8
[56]   Apoptosis, autophagy and atherosclerosis: Relationships and the role of Hsp27 [J].
Shan, Ruiting ;
Liu, Ning ;
Yan, Youyou ;
Liu, Bin .
PHARMACOLOGICAL RESEARCH, 2021, 166
[57]   Mon2 predicts poor outcome in ST-elevation myocardial infarction [J].
Shantsila, E. ;
Ghattas, A. ;
Griffiths, H. R. ;
Lip, G. Y. H. .
JOURNAL OF INTERNAL MEDICINE, 2019, 285 (03) :301-316
[58]   Free Light Chains in patients with acute coronary syndromes: Relationships to inflammation and renal function [J].
Shantsila, Eduard ;
Tapp, Luke D. ;
Lip, Gregory Y. H. .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2015, 185 :322-327
[59]   Receptors to interleukin-6 and adhesion molecules on circulating monocyte subsets in acute myocardial infarction [J].
Shantsila, Eduard ;
Tapp, Luke D. ;
Wrigley, Benjamin J. ;
Montoro-Garcia, Silvia ;
Lip, Gregory Y. H. .
THROMBOSIS AND HAEMOSTASIS, 2013, 110 (02) :340-348
[60]   CXCR4 positive and angiogenic monocytes in myocardial infarction [J].
Shantsila, Eduard ;
Tapp, Luke D. ;
Wrigley, Benjamin J. ;
Montoro-Garcia, Silvia ;
Lip, Gregory Y. H. .
THROMBOSIS AND HAEMOSTASIS, 2013, 109 (02) :255-262