Astaxanthin attenuates doxorubicin-induced liver injury via suppression of ferroptosis in rats

被引：3

作者：

Yin, Bowen ^{[1
]}

Ren, Jingyi ^{[1
]}

Liu, Xuanyi ^{[1
]}

Lu, Miaomiao ^{[1
]}

Huang, Dan ^{[2
]}

Zhang, Yadong ^{[1
]}

Zuo, Jinshi ^{[1
]}

Wen, Rui ^{[1
]}

Pei, Huanting ^{[1
]}

Zhu, Siqi ^{[1
]}

Zhang, Zhenao ^{[1
]}

Wang, Ziyi ^{[2
]}

Ma, Yuxia ^{[1
]}

机构：

[1] Hebei Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Hebei Key Lab Environm & Human Hlth, Shijiazhuang 050017, Peoples R China

[2] Hebei Med Univ, Undergrad Coll Publ Hlth, Shijiazhuang 050017, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2024年 / 121卷

基金：

中国国家自然科学基金;

关键词：

Astaxanthin; Doxorubicin; Hepatotoxicity; Iron accumulation; Ferroptosis; OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; CANCER STATISTICS; HEPATOTOXICITY; DAMAGE; CARDIOTOXICITY; INHIBITION; CHELATION;

D O I：

10.1016/j.jff.2024.106437

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Hepatotoxicity is an significant side effect of doxorubicin (DOX), while astaxanthin (ASX) has the anti-liver injury biological functions. In this study, we utilized in vivo and in vitro methods to investigate the protective effect of ASX against DOX-induced hepatotoxicity and elucidate its potential mechanism. Our researchers measured liver injury indicators and the expression of ferroptosis-related protein (transferrin receptor 1 (TFRC), ferroportin 1 (FPN1), ferritin light chain (FTL), ferritin heavy chain-1 (FTH1), glutathione peroxidase 4 (GPX4), and solute carrier family 7 member 11 (SLC7A11)) in rats and HepG2 cells. We found that ASX could effectively reduce ferroptosis level and relieve a range of DOX-caused manifestations of liver injury, including inflammation and oxidative damage. ASX may play the same role as ferroptosis inhibitor, Fer-1 and DFP, in this process. The findings demonstrated that the intervention with ASX ameliorated the DOX-induced liver injury by mitigating the DOX-induced ferroptosis through inhibiting iron accumulation.

引用

页数：12

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