Advancements in the study of T lymphocytes in thoracic aortic aneurysm and aortic dissection

被引：0
作者：
Chen, Baolin [1 ,2 ]
Wang, Xueling [1 ,2 ]
Jiang, Bo [1 ,2 ]
Xin, Shijie [1 ,2 ]
机构：
[1] China Med Univ, Affiliated Hosp 1, Dept Vasc Surg, Shenyang, Peoples R China
[2] Key Lab Pathogenesis Prevent & Therapeut Aort Aneu, Shenyang, Liaoning, Peoples R China
来源：
TISSUE & CELL | 2025年 / 93卷
基金：
中国国家自然科学基金;
关键词：
Thoracic aortic aneurysms and dissection; Inflammation; T lymphocytes; Cytokines; Vascular Immunity; CELLS; PATHWAY;
D O I：
10.1016/j.tice.2025.102768
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Thoracic aortic aneurysms and dissection (TAAD) is a critical, life-threatening cardiovascular condition characterized by immune-mediated inflammatory infiltration and structural degradation of the aorta wall, which are pivotal in its etiology. In recent years, the significance of T lymphocytes in TAAD has increasingly garnered scientific attention. TAAD is a multifaceted vascular disorder characterized by the involvement of many immune cells, with T lymphocytes playing a pivotal role, particularly in the modulation of inflammatory responses, immunological control, and tissue damage. A comprehensive understanding of the T lymphocyte activation process in TAAD is crucial for the advancement of novel preventative and therapy strategies. This article evaluates the recent research advancements on the function of T lymphocytes in TAAD, aiming to offer novel insights for the future prevention and treatment of TAAD.
引用
收藏
页数：7
相关论文
共 50 条
[41]   Causal Role for Neutrophil Elastase in Thoracic Aortic Dissection in Mice [J].
Yang, Mei ;
Zhou, Xinmiao ;
Pearce, Stuart W. A. ;
Yang, Zhisheng ;
Chen, Qishan ;
Niu, Kaiyuan ;
Liu, Chenxin ;
Luo, Jun ;
Li, Dan ;
Shao, Yue ;
Zhang, Cheng ;
Chen, Dan ;
Wu, Qingchen ;
Cutillas, Pedro R. ;
Zhao, Lin ;
Xiao, Qingzhong ;
Zhang, Li .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2023, 43 (10) :1900-1920
[42]   Alteration of Blood Oxidative Stress Status in Patients with Thoracic Aortic Dissection: A Pilot Study [J].
Pincemail, Joel ;
Tchana-Sato, Vincent ;
Courtois, Audrey ;
Musumeci, Lucia ;
Cheramy-Bien, Jean-Paul ;
Munten, Jacobine ;
Labropoulos, Nicos ;
Defraigne, Jean-Olivier ;
Sakalihasan, Natzi .
ANTIOXIDANTS, 2023, 12 (05)
[43]   Genetic liability to elevated circulating IP-10, IFN γ and SCGF β levels in relation to thoracic aortic aneurysm: A mendelian randomization study [J].
Ye, Qianxi ;
Chen, Miao ;
Ma, Liang .
CYTOKINE, 2024, 178
[44]   Rapid Progression of Aortic Regurgitation with Thoracic Aortic Aneurysm due to Takayasu Arteritis Associated with Ulcerative Colitis [J].
Kashima, Katsuro ;
Kawasaki, Daisuke ;
Yotsumoto, Goichi ;
Hatake, Shinsaku ;
Yamashita, Erika ;
Nagayoshi, Shinya ;
Yoshishige, Yusuke ;
Tanoue, Kazuyuki ;
Nagano, Shinjirou ;
Tanaka, Hideki ;
Nuruki, Norihito ;
Sonoda, Masahiro .
INTERNAL MEDICINE, 2010, 49 (11) :1007-1011
[45]   Preoperative proteinuria and clinical outcomes in type B aortic dissection after thoracic endovascular aortic repair [J].
Yang, Hongwei ;
Zhou, Jianwei ;
Huang, Keli ;
Yu, Tao ;
Wang, Zuhui ;
Chen, Heng ;
Yu, Wenshui ;
Lin, Xiaodong ;
Zhang, Yan ;
Zhu, Guoxian .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2019, 57 (05) :752-758
[46]   Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice [J].
Ren, Pingping ;
Hughes, Michael ;
Krishnamoorthy, Swapna ;
Zou, Sili ;
Zhang, Lin ;
Wu, Darrell ;
Zhang, Chen ;
Curci, John A. ;
Coselli, Joseph S. ;
Milewicz, Dianna M. ;
LeMaire, Scott A. ;
Shen, Ying H. .
SCIENTIFIC REPORTS, 2017, 7
[47]   Interleukin-3 stimulates matrix metalloproteinase 12 production from macrophages promoting thoracic aortic aneurysm/dissection [J].
Liu, Chang ;
Zhang, Congcong ;
Jia, Lixin ;
Chen, Boya ;
Liu, Luxin ;
Sun, Jie ;
Zhang, Wenmei ;
You, Bin ;
Li, Yulin ;
Li, Ping ;
Du, Jie .
CLINICAL SCIENCE, 2018, 132 (06) :655-668
[48]   Increased interleukin-11 levels in thoracic aorta and plasma from patients with acute thoracic aortic dissection [J].
Xu, Yao ;
Ye, Jing ;
Wang, Menglong ;
Wang, Yuan ;
Ji, Qingwei ;
Huang, Ying ;
Zeng, Tao ;
Wang, Zhen ;
Ye, Di ;
Jiang, Huimin ;
Liu, Jianfang ;
Lin, Yingzhong ;
Wan, Jun .
CLINICA CHIMICA ACTA, 2018, 481 :193-199
[49]   Detection of Pathological Changes in the Aorta during Thoracic Aortic Aneurysm Progression on Molecular Level [J].
Rabajdova, Miroslava ;
Urban, Peter ;
Spakova, Ivana ;
Panagiotis, Artemiou ;
Ferencakova, Michaela ;
Rybar, Dusan ;
Bobrov, Nikita ;
Sabol, Frantisek ;
Marekova, Maria .
DISEASE MARKERS, 2017, 2017
[50]   Involvement of B cells in the pathophysiology of β-aminopropionitrile-induced thoracic aortic dissection in mice [J].
Gao, Yanxiang ;
Wang, Zhizhi ;
Zhao, Jianqiao ;
Sun, Weiliang ;
Guo, Jing ;
Yang, Zufang ;
Tu, Yimin ;
Yu, Changan ;
Pan, Lin ;
Zheng, Jingang .
EXPERIMENTAL ANIMALS, 2019, 68 (03) :331-339
12345