The function of serine/threonine-specific protein kinases in B cells

被引：3

作者：

Han, Zhennan ^{[1
,2
]}

Benlagha, Kamel ^{[3
]}

Lee, Pamela ^{[4
]}

Park, Chan-Sik ^{[5
]}

Filatov, Alexander ^{[6
]}

Byazrova, Maria G. ^{[6
]}

Miller, Heather ^{[7
]}

Yang, Lu ^{[1
,2
]}

Liu, Chaohong ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathogen Biol, Wuhan, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, State Key Lab Diag & Treatment Severe Zoonot Infec, Wuhan, Hubei, Peoples R China

[3] Univ Paris, Inst Rech St Louis, EMiLy, Paris, France

[4] Univ Hong Kong, Li Ka Shing Fac Med, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China

[5] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul, South Korea

[6] Fed Med Biol Agcy Russia, Natl Res Ctr Inst Immunol, Lab Immunochem, Moscow, Russia

[7] Cytek Biosci, R&D Clin Reagents, Fremont, CA USA

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

关键词：

STK family protein; B cell; cell differentiation; cell proliferation; B cell activation; FACTOR-KAPPA-B; BRUTONS TYROSINE KINASE; MICE LACKING; ZETA-PKC; RECEPTOR; ACTIVATION; BETA; DIFFERENTIATION; PROLIFERATION; LYMPHOCYTES;

D O I：

10.3389/fimmu.2024.1459527

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The serine/threonine-specific protein kinases (STKs) are important for cell survival, proliferation, differentiation, and apoptosis. In B cells, these kinases play indispensable roles in regulating important cellular functions. Multiple studies on human and other animal cells have shown that multiple STKs are involved in different stages of B cell development and antibody production. However, how STKs affect B cell development and function is still not completely understood. Considering that B cells are clinically important in immunity and diseases, our understanding of STKs' roles in B cells is in great need of investigation with current technologies. Investigating serine/threonine kinases will not only deepen our insight into B cell-related disorders but also facilitate the identification of more effective drug targets for conditions like lymphoma and systemic lupus erythematosus.

引用

页数：11

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