Neoadjuvant treatment for pancreatic cancer: Controversies and advances

被引:1
|
作者
Silva, Douglas Dias [1 ]
Chung, Vincent [1 ]
机构
[1] City Hope Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA
关键词
Pancreas cancer; Neoadjuvant therapy; IMMEDIATE SURGERY; FOLFIRINOX; THERAPY; CHEMORADIOTHERAPY; GEMCITABINE; CHEMOTHERAPY; MULTICENTER; BIOMARKERS; SURVIVAL; TRIAL;
D O I
10.1016/j.ctarc.2024.100804
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Despite the advancements in the treatment of localized pancreatic cancer, several unresolved issues persist in clinical practice, especially in the neoadjuvant setting. These include determining the criteria for selecting patients for treatment, identifying the most effective chemotherapy regimens, understanding the role of radiotherapy, and accurately assessing how patients respond to treatment. Current strategies for assessing patients before surgery involve thoroughly evaluating their overall health status, analyzing tumor markers, and using advanced imaging techniques. However, existing methods for staging the disease still have limitations when it comes to accurately detecting metastatic cancer. The ongoing debate between performing surgery upfront or administering neoadjuvant therapy highlights the need for robust clinical evidence to guide treatment decisions effectively. This review analyzes the evidence regarding controversial topics in neoadjuvant pancreatic cancer treatment and discusses further research efforts to enhance patient outcomes. To improve the outcomes found with surgery alone, multimodal treatment with chemotherapy.
引用
收藏
页数:7
相关论文
共 50 条
  • [41] Pancreatic Cancer: Advances in Treatment, Results and Limitations
    Hackert, Thilo
    Buechler, Markus W.
    DIGESTIVE DISEASES, 2013, 31 (01) : 51 - 56
  • [42] Current therapies and advances in the treatment of pancreatic cancer
    Mancuso, Andrea
    Calabro, Fabio
    Sternberg, Cora N.
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2006, 58 (03) : 231 - 241
  • [43] Recent advances in the surgical treatment of pancreatic cancer
    AShankar
    RCGRussell
    World Journal of Gastroenterology, 2001, (05) : 622 - 626
  • [44] Recent advances in diagnosis and treatment of pancreatic cancer
    Nakao, A
    HEPATO-GASTROENTEROLOGY, 2001, 48 (40) : 913 - 915
  • [45] New Advances in the Treatment of Metastatic Pancreatic Cancer
    Schober, Marvin
    Javed, Muhammad A.
    Beyer, G.
    Le, Nha
    Vinci, Alessio
    Sund, Malin
    Neesse, Albrecht
    Krug, Sebastian
    DIGESTION, 2015, 92 (03) : 175 - 184
  • [46] Controversies in pancreatic cancer surgery
    Morera-Ocon, Francisco J.
    CIRUGIA ESPANOLA, 2011, 89 (06): : 411 - 411
  • [47] Advances in neoadjuvant therapy for resectable pancreatic cancer over the past two decades
    Taboada, Alvaro Gregorio Morales
    Lominchar, Pablo Lozano
    Roman, Lorena Martin
    Garcia-Alfonso, Pilar
    Martin, Andres Jesus Munoz
    Rodriguez, Jose Antonio Blanco
    Pascual, Jose Manuel Asencio
    ANNALS OF HEPATO-BILIARY-PANCREATIC SURGERY, 2021, 25 (02) : 179 - 191
  • [48] KIDNEY CANCER Progress and controversies in neoadjuvant therapy
    Posadas, Edwin M.
    Figlin, Robert A.
    NATURE REVIEWS UROLOGY, 2014, 11 (05) : 254 - 255
  • [49] Controversies in breast cancer: adjuvant and neoadjuvant therapy
    Montemurro, F
    Redana, S
    Valabrega, G
    Aglietta, M
    EXPERT OPINION ON PHARMACOTHERAPY, 2005, 6 (07) : 1055 - 1072
  • [50] Current Controversies in Neoadjuvant Chemoradiation of Rectal Cancer
    Phang, P. Terry
    Wang, Xiaodong
    SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 2014, 23 (01) : 79 - +