Selective Synthesis of 2-(Indol-3-Yl)Phenols via Iodine-Catalyzed C3-Arylation of Indoles with Cyclohexanones

被引：0
|
作者：
Yin, Qi [1 ]
Zhou, Xinlin [1 ]
Zhang, Chao [1 ]
Chen, Shanping [1 ]
Li, Yuxia [1 ]
Deng, Guo-Jun [1 ,2 ]
机构：
[1] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem,Key Lab Green Organ, Xiangtan 411105, Peoples R China
[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2025年
基金：
中国国家自然科学基金;
关键词：
Aromatization; C-H functionalization; Arylation; Oxygenation; Transition-metal-free; STRUCTURE-BASED DESIGN; DIRECT ARYLATION; SUBSTITUTED CYCLOHEXANONES; AEROBIC DEHYDROGENATION; ROOM-TEMPERATURE; PALLADIUM; MILD; 3-NAPHTHYLINDOLE; ANTIBACTERIAL; CYCLOHEXENONE;
D O I：
10.1002/adsc.202401507
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An iodine-catalyzed C3-arylation of indoles with cyclohexanones to selectively synthesize 2-(indol-3-yl)phenols has been described. Mechanism studies indicate that the oxygen atom in 2-(indol-3-yl)phenols is originally from DMSO. This cascade involving dehydration condensation, selective oxygenation, dehydrogenation, and aromatization was achieved in one pot under transition-metal-free conditions.
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页数：7
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