Association between rs3761548 polymorphism of FOXP3 and the risk of gastric cancer: a case-control study

被引：0

作者：

Validi, Shamimeh ^{[1
]}

Saadat, Iraj ^{[1
]}

机构：

[1] Shiraz Univ, Fac Sci, Dept Biol, Shiraz 7146713565, Iran

来源：

MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS | 2024年 / 13卷 / 04期

关键词：

FOXP3; Gastric Cancer; Genetic Polymorphisms; PCR-RFLP; REGULATORY T-CELLS; EXPRESSION;

D O I：

10.22099/mbrc.2024.49125.1989

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastric cancer is one of the most prevalent malignancies in the world. Various factors play a role in the development of this disease as risk factors. One of these genes is the FOXP3, , which is located on the short arm of the X chromosome (Xp11.23). The rs3761548 polymorphism in the promoter region of this gene increases cell proliferation. In the current study, the association between this genetic polymorphism and the risk of gastric cancer was investigated. This study included 147 patients (55 women, 92 men) with gastric cancer and 147 healthy individuals (53 women, 94 men). The PCR-RFLP method is used for genotyping. Statistical analysis showed that there was no significant association between this polymorphism and the risk of gastric cancer. However, the analysis of genotype, family history and smoking risk factors simultaneoussly revealed a significant relationship between simultaneous occurrence of two (OR=3.79, 95% CI=1.77-8.09, p=0.001) and three risk factors (OR=6.44, 95% CI=1.76-23.5, p=0.017) and the risk of gastric cancer.

引用

页码：247 / 252

页数：6

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