Aortic dimensions in women with previous pre-eclampsia

被引:1
作者
Moller, Emma L. R. [1 ]
Hauge, Maria G. [1 ,2 ]
Pham, Michael H. C. [1 ]
Damm, Peter [2 ,3 ]
Kofoed, Klaus F. [1 ,3 ,5 ]
Fuchs, Andreas [1 ]
Kuhl, Jorgen T. [1 ]
Sigvardsen, Per E. [1 ,4 ]
Ersboll, Anne S. [2 ]
Johansen, Marianne [2 ]
Nordestgaard, Borge G. [1 ,3 ]
V. Kober, Lars [1 ]
Gustafsson, Finn [1 ,3 ]
Linde, Jesper J. [1 ]
机构
[1] Copenhagen Univ Hosp, Heart Ctr, Dept Cardiol, Rigshosp, Sect 2141,Blegdamsvej 9, DK-2100 Copenhagen, Denmark
[2] Copenhagen Univ Hosp, Dept Obstet, Rigshosp, Copenhagen, Denmark
[3] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark
[4] Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Copenhagen Gen Populat Study, Herlev, Denmark
[5] Copenhagen Univ Hosp, Diagnost Ctr, Dept Radiol, Rigshosp, Copenhagen, Denmark
关键词
Pre-eclampsia; Cardiac risk assessment in women; Aortic dimensions; Aortic aneurysms; CARDIOVASCULAR-DISEASE RISK; THICKNESS;
D O I
10.1016/j.jcct.2024.06.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Pre-eclampsia is a pregnancy related disorder associated with hypertension and vascular inflammation, factors that are also involved in the pathological pathway of aortic dilatation and aneurysm development. It is, however, unknown if younger women with previous pre-eclampsia have increased aortic dimensions. We tested the hypothesis that previous pre-eclampsia is associated with increased aortic dimensions in younger women. Methods: The study was a cross-sectional cohort study of women with previous pre-eclampsia, aged 40-55, from the PRECIOUS population matched by age and parity with women from the general population. Using contrastenhanced CT, aortic diameters were measured in the aortic root, ascending aorta, descending aorta, at the level of the diaphragm, suprarenal aorta, and infrarenal aorta. Results: 1355 women (684 with previous pre-eclampsia and 671 from the general population), with a mean (standard deviation) age of 46.9 (4.4) were included. The pre-eclampsia group had larger mean (standard deviation) aortic diameters (mm) in all measured segments from the ascending to the infrarenal aorta (ascending: 33.4 (4.0) vs. 31.4 (3.7), descending: 23.9 (2.1) vs. 23.3 (2.0), diaphragm: 20.8 (1.8) vs. 20.4 (1.8), suprarenal: 22.9 (1.9) vs. 22.0 (2.0), infrarenal: 19.3 (1.6) vs. 18.6 (1.7), p < 0.001 for all, also after adjustment for age, height, parity, menopause, dyslipidemia, smoking and chronic hypertension. Guideline-defined ascending aortic aneurysms were found in 8 vs 2 women (p 1/4 0.12). Conclusions: Women with previous pre-eclampsia have larger aortic dimensions compared with women from the general population. Pre-eclampsia was found to be an independent risk factor associated with a larger aortic diameter.
引用
收藏
页码:533 / 540
页数:8
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