Elaeagnus latifolia Fruit Extract Ameliorates High-Fat Diet-Induced Obesity in Mice and Alleviates Macrophage-Induced Inflammation in Adipocytes In Vitro

被引:2
作者
Munkong, Narongsuk [1 ]
Jantarach, Nattanida [2 ]
Yoysungnoen, Bhornprom [3 ]
Lonan, Piyanuch [4 ]
Makjaroen, Jiradej [5 ,6 ]
Pearngam, Phorutai [7 ]
Kumpunya, Sarinya [8 ,9 ]
Ruxsanawet, Kingkarnonk [2 ]
Nanthawong, Saharat [6 ]
Somparn, Poorichaya [6 ]
Thim-Uam, Arthid [10 ]
机构
[1] Univ Phayao, Sch Med, Dept Pathol, Phayao 56000, Thailand
[2] Univ Phayao, Sch Publ Hlth, Appl Thai Tradit Med Program, Phayao 56000, Thailand
[3] Thammasat Univ, Fac Med, Dept Preclin Sci, Div Physiol, Pathum Thani 12120, Thailand
[4] Univ Phayao, Sch Publ Hlth, Tradit Chinese Med Program, Phayao 56000, Thailand
[5] Chulalongkorn Univ, Fac Allied Hlth Sci, Dept Transfus Med & Clin Microbiol, Bangkok 10330, Thailand
[6] Chulalongkorn Univ, Fac Med, Ctr Excellence Syst Biol, Bangkok 10330, Thailand
[7] Mahidol Univ, Int Coll, Nakhon Pathom 73170, Thailand
[8] Chulalongkorn Univ, Fac Med, Dept Med, Div Infectious Dis, Bangkok 10330, Thailand
[9] King Chulalongkorn Mem Hosp, Thai Red Cross Soc, Bangkok 10330, Thailand
[10] Univ Phayao, Sch Med Sci, Div Biochem, Phayao 56000, Thailand
关键词
Elaeagnus latifolia; obesity; inflammation; macrophages infiltration; energy-producing pathways; ADIPOSE-TISSUE; PPAR-GAMMA; ADIPOGENESIS; EXPRESSION; DIFFERENTIATION; INHIBITION; ITACONATE; GENES; L;
D O I
10.3390/antiox13121485
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Elaeagnus latifolia (EL) is a wild fruit known for containing several health-promoting compounds. This study aimed to evaluate the effects of EL fruit extract on high-fat diet (HFD)-induced obesity and lipopolysaccharide (LPS)-activated macrophages. Mice fed an HFD and given EL fruit extract for 10 weeks exhibited significantly lower body weight, reduced lipid accumulation, diminished oxidative stress in adipocytes, and decreased macrophage infiltration compared to those not receiving the EL extract. Moreover, the EL fruit extract activated the transcription factors Pparg and Cebpa, initiating adipogenesis and modulating the expression of NF-kappa B/Nrf-2-induced target genes. This resulted in smaller adipocyte size, reduced inflammation, and less oxidative stress in HFD-fed mice. In vitro, the EL extract induced a shift in macrophage phenotype from M1 to M2, reduced I kappa B alpha/NF-kappa B phosphorylation, and effectively decreased energy production in macrophages by downregulating the expression of several proteins involved in glycolysis and the tricarboxylic acid cycle. This mechanistic study suggests that administering EL fruit extract could be an effective strategy for managing obesity and its associated pathologies.
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页数:23
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