Mucosal Inflammatory Memory in Chronic Rhinosinusitis

被引：0

作者：

Koo, Min-Seok ^{[1
]}

Moon, Sungmin ^{[1
]}

Rha, Min-Seok ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Otorhinolaryngol, Seoul 03722, South Korea

来源：

CELLS | 2024年 / 13卷 / 23期

基金：

新加坡国家研究基金会;

关键词：

chronic rhinosinusitis; inflammatory memory; mucosal immunity; trained immunity; THYMIC STROMAL LYMPHOPOIETIN; AIRWAY EPITHELIAL-CELLS; INNATE LYMPHOID-CELLS; T-CELLS; HEMATOPOIETIC STEM; TRAINED IMMUNITY; NASAL POLYPS; DISEASE; ACTIVATION; POPULATION;

D O I：

10.3390/cells13231947

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent advancements in medical management, endoscopic sinus surgery, and biologics have significantly improved outcomes for patients with chronic rhinosinusitis (CRS). However, long-term recurrence is frequently observed following endoscopic sinus surgery, with symptoms worsening after biologics are discontinued. Consequently, refractory or recurrent CRS remains a significant challenge, causing a substantial healthcare burden. In this review, we provide current insights into mucosal inflammatory memory, a potential mechanism leading to CRS recurrence. Given that both immune and non-immune cells in the sinonasal mucosa play critical roles in the pathophysiology of CRS, a deeper understanding of the mechanisms underlying mucosal inflammatory memory in various cellular components of sinonasal tissue could aid in the management of refractory CRS. We describe and discuss the latest knowledge regarding the novel concept of inflammatory memory, including both adaptive immune memory and trained immunity. Additionally, we summarize the pathogenic memory features of the sinonasal mucosa cellular components in the context of CRS.

引用

页数：19

共 50 条

[31] Anti-inflammatory effect of bee venom in an allergic chronic rhinosinusitis mouse model [J].

Shin, Seung-Heon ;

Ye, Mi-Kyung ;

Choi, Sung-Yong ;

Park, Kwan-Kyu .

MOLECULAR MEDICINE REPORTS, 2018, 17 (05) :6632-6638

[32] Biofilms and mucosal healing in postsurgical patients with chronic rhinosinusitis [J].

Zhang, Zi ;

Han, Demin ;

Zhang, Shengzhong ;

Han, Yehua ;

Dai, Wei ;

Fan, Erzhong ;

Li, Ying ;

Li, Yunchuan ;

Wang, Deyun .

AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 2009, 23 (05) :506-511

[33] Association of Mucosal Organisms with Patterns of Inflammation in Chronic Rhinosinusitis [J].

Chalermwatanachai, Thanit ;

Zhang, Nan ;

Holtappels, Gabriele ;

Bachert, Claus .

PLOS ONE, 2015, 10 (08)

[34] Clinical implications of mucosal remodeling from chronic rhinosinusitis [J].

Do, Timothy Q. ;

Barham, Henry P. ;

Earls, Peter ;

Sacks, Raymond ;

Christensen, Jenna M. ;

Rimmer, Janet ;

Harvey, Richard J. .

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY, 2016, 6 (08) :835-840

[35] Chloroquine Treatment Suppresses Mucosal Inflammation in a Mouse Model of Eosinophilic Chronic Rhinosinusitis [J].

Choi, Mi-Ra ;

Xu, Jun ;

Lee, Seulgi ;

Yeon, Sun-Hee ;

Park, Soo-Kyoung ;

Rha, Ki-Sang ;

Kim, Yong Min .

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 2020, 12 (06) :994-1011

[36] Relationship between histologic changes and inflammatory markers in chronic rhinosinusitis [J].

Pyo, Jung-Soo ;

Kim, Su Jin .

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2021, 14 (04) :501-507

[37] In Vitro Effects of Doxycycline on Inflammatory Cytokines and Gelatinases in Chronic Rhinosinusitis [J].

Sommer, J. Ulrich ;

Schultz, Johannes D. ;

Grossbaier, Judith ;

Stern-Straeter, Jens ;

Hoermann, Karl ;

Sauter, Alexander .

IN VIVO, 2012, 26 (03) :369-374

[38] Associations Between Inflammatory Endotypes and Clinical Presentations in Chronic Rhinosinusitis [J].

Stevens, Whitney W. ;

Peters, Anju T. ;

Tan, Bruce K. ;

Klingler, Aiko I. ;

Poposki, Julie A. ;

Hulse, Kathryn E. ;

Grammer, Leslie C. ;

Welch, Kevin C. ;

Smith, Stephanie S. ;

Conley, David B. ;

Kern, Robert C. ;

Schleimer, Robert P. ;

Kato, Atsushi .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2019, 7 (08) :2812-+

[39] Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers [J].

Tomassen, Peter ;

Vandeplas, Griet ;

Van Zele, Thibaut ;

Cardell, Lars-Olaf ;

Arebro, Julia ;

Olze, Heidi ;

Foerster-Ruhrmann, Ulrike ;

Kowalski, Marek L. ;

Olszewska-Ziaber, Agnieszka ;

Holtappels, Gabriele ;

De Ruyck, Natalie ;

Wang, Xiangdong ;

Van Drunen, Cornelis ;

Mullol, Joaquim ;

Hellings, Peter ;

Hox, Valerie ;

Toskala, Elina ;

Scadding, Glenis ;

Lund, Valerie ;

Zhang, Luo ;

Fokkens, Wytske ;

Bachert, Claus .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 137 (05) :1449-+

[40] Eotaxin-3 as a Plasma Biomarker for Mucosal Eosinophil Infiltration in Chronic Rhinosinusitis [J].

Yamada, Takechiyo ;

Miyabe, Yui ;

Ueki, Shigeharu ;

Fujieda, Shigeharu ;

Tokunaga, Takahiro ;

Sakashita, Masafumi ;

Kato, Yukinori ;

Ninomiya, Takahiro ;

Kawasaki, Yohei ;

Suzuki, Shinsuke ;

Saito, Hidekazu .

FRONTIERS IN IMMUNOLOGY, 2019, 10

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