Molecular mechanisms of renal cell carcinoma metastasis and potential targets for therapy

被引：0
作者：
Li, Xinwei [1 ,2 ]
Xiong, Wei [3 ]
Xiong, Zhiyong [1 ,2 ]
Zhang, Xiaoping [1 ,2 ,4 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Urol, Wuhan, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Inst Urol, Tongji Med Coll, Wuhan, Peoples R China
[3] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Nephrol, Wuhan, Peoples R China
[4] Shenzhen Huazhong Univ Sci & Technol, Res Inst, Shenzhen, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2025年 / 13卷
基金：
中国国家自然科学基金;
关键词：
renal cell carcinoma; metastasis; metastatic renal cell carcinoma; molecular mechanisms; targeted therapy; PATHWAY; PROLIFERATION; CABOZANTINIB;
D O I：
10.3389/fcell.2025.1521151
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Renal cell carcinoma is a common type of cancer, with approximately 30% of patients potentially developing metastatic disease. Some patients with metastatic renal cell carcinoma are found in advanced stages, so the 5-year survival rate for metastatic renal cell carcinoma is only 14%. Currently, there are several drugs available for patients with metastatic renal cell carcinoma, and their overall survival can be extended to nearly 5 years. However, the sensitivity and efficacy of the treatment are still unsatisfactory. New targets and drugs to improve patient prognosis are urgently needed, but these are closely linked to the molecular mechanisms of renal cell carcinoma metastasis. In this review, we present the definition and common molecular mechanisms of metastatic renal cell carcinoma and provide new insights on their potential link to targeted therapies, which may enlighten scientists to develop future targeted therapeutic agents to improve the prognosis of patients with metastatic renal cell carcinoma.
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页数：9
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