Neutralizing Antibody Responses to Chlamydia trachomatis in Women and Associations With Chlamydia Outcomes

被引：3
作者：
Yu, Hong [1 ]
Geisler, William M. [2 ]
Dai, Chuanbin [1 ]
Gupta, Kanupriya [2 ]
Cutter, Gary [3 ]
Brunham, Robert C. [1 ]
机构：
[1] Univ British Columbia, British Columbia Ctr Dis Control, Vancouver, BC, Canada
[2] Univ Alabama Birmingham, Dept Med, Birmingham, AL USA
[3] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2024年 / 231卷 / 03期
基金：
美国国家卫生研究院;
关键词：
chlamydia infection; clinical outcomes; neutralizing antibody; serology; women; INFECTION; IMMUNITY; PROTECTION;
D O I：
10.1093/infdis/jiae519
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We assessed neutralizing antibody responses in a well-characterized cohort of 60 women with different Chlamydia trachomatis infection outcomes noted at a treatment visit and 3-month follow-up. We found varying rates of neutralization (inhibition of C trachomatis) in sera at different dilution levels and varying neutralizing antibody titers across outcomes. Median neutralization rates were significantly higher in sera at high dilutions (1:320-1:1280) from women with spontaneous resolution vs persisting infection before treatment (all P < .05). These findings suggest that neutralizing antibody responses may contribute to protective immunity against chlamydia.
引用
收藏
页码：e531 / e535
页数：5
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