Neutralizing Antibody Responses to Chlamydia trachomatis in Women and Associations With Chlamydia Outcomes

被引：3

作者：

Yu, Hong ^{[1
]}

Geisler, William M. ^{[2
]}

Dai, Chuanbin ^{[1
]}

Gupta, Kanupriya ^{[2
]}

Cutter, Gary ^{[3
]}

Brunham, Robert C. ^{[1
]}

机构：

[1] Univ British Columbia, British Columbia Ctr Dis Control, Vancouver, BC, Canada

[2] Univ Alabama Birmingham, Dept Med, Birmingham, AL USA

[3] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2024年 / 231卷 / 03期

基金：

美国国家卫生研究院;

关键词：

chlamydia infection; clinical outcomes; neutralizing antibody; serology; women; INFECTION; IMMUNITY; PROTECTION;

D O I：

10.1093/infdis/jiae519

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed neutralizing antibody responses in a well-characterized cohort of 60 women with different Chlamydia trachomatis infection outcomes noted at a treatment visit and 3-month follow-up. We found varying rates of neutralization (inhibition of C trachomatis) in sera at different dilution levels and varying neutralizing antibody titers across outcomes. Median neutralization rates were significantly higher in sera at high dilutions (1:320-1:1280) from women with spontaneous resolution vs persisting infection before treatment (all P < .05). These findings suggest that neutralizing antibody responses may contribute to protective immunity against chlamydia.

引用

页码：e531 / e535

页数：5

共 50 条

[31] Comparison of four serological assays for the diagnosis of Chlamydia trachomatis in subfertile women [J].

Muvunyi, Claude Mambo ;

Claeys, Laurens ;

De Sutter, Tineka ;

De Sutter, Petra ;

Temmerman, Marleen ;

Van Renterghem, Lieve ;

Claeys, Geert ;

Padalko, Elizaveta .

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2012, 6 (05) :396-402

[32] Lateral flow-based antibody testing for Chlamydia trachomatis [J].

Gwyn, Sarah ;

Mitchell, Alexandria ;

Dean, Deborah ;

Mkocha, Harran ;

Handali, Sukwan ;

Martin, Diana L. .

JOURNAL OF IMMUNOLOGICAL METHODS, 2016, 435 :27-31

[33] Considerations on Chlamydia trachomatis disease expression [J].

Brunham, Robert C. ;

Rekart, Michael L. .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2009, 55 (02) :162-166

[34] Problems With Understanding Chlamydia trachomatis Immunology [J].

Brunham, Robert C. .

JOURNAL OF INFECTIOUS DISEASES, 2022, 225 (11) :2043-2049

[35] Systemic Antibody Response to Chlamydia Trachomatis Infection in Patients Either Infected or Reinfected with Different Chlamydia Serovars [J].

Gupta, Vivek Kumar ;

Waugh, Courtney Alice ;

Ziklo, Noa ;

Huston, Wilhelmina M. ;

Hocking, Jane S. ;

Timms, Peter .

INDIAN JOURNAL OF MEDICAL MICROBIOLOGY, 2017, 35 (03) :394-401

[36] Chlamydia trachomatis: The enemy of the Fallopian tube [J].

Bohbot, J. -M. .

GYNECOLOGIE OBSTETRIQUE & FERTILITE, 2011, 39 (11) :636-639

[37] Chlamydia trachomatis control requires a vaccine [J].

Brunham, Robert C. ;

Rappuoli, Rino .

VACCINE, 2013, 31 (15) :1892-1897

[38] Seroprevalence of Chlamydia trachomatis in Enugu, Nigeria [J].

Ikeme, A. C. ;

Ezegwui, H. U. ;

Ikeako, L. C. ;

Agbata, I. ;

Agbata, E. .

NIGERIAN JOURNAL OF CLINICAL PRACTICE, 2011, 14 (02) :176-180

[39] Sphingolipid Metabolism and Transport in Chlamydia trachomatis and Chlamydia psittaci Infections [J].

Banhart, Sebastian ;

Schaefer, Elena K. ;

Gensch, Jean-Marc ;

Heuer, Dagmar .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019, 7

[40] Tests for infection with Chlamydia trachomatis [J].

TaylorRobinson, D .

INTERNATIONAL JOURNAL OF STD & AIDS, 1996, 7 (01) :19-26

← 1 2 3 4 5 →