Photoinitiated Nitric Oxide Release as an Antibacterial Treatment for Chronic Wounds

被引：1

作者：

Johnson, Courtney R. ^{[1
]}

Schoenfisch, Mark H. ^{[1
,2
]}

机构：

[1] Univ North Carolina Chapel Hill, Dept Chem, Chapel Hill, NC 27599 USA

[2] Univ North Carolina Chapel Hill, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2025年 / 11卷 / 03期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

nitric oxide; mesoporous silica nanoparticles; S-nitrosothiols; light-mediated release; chronic wound pathogen; BLUE-LIGHT; IN-VITRO; ENHANCED ANTIBACTERIAL; PHOTODYNAMIC THERAPY; MESOPOROUS SILICA; NANOPARTICLES; MANAGEMENT; INACTIVATION; IRRADIATION; AERUGINOSA;

D O I：

10.1021/acsbiomaterials.4c01955

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Taking advantage of their innate roles as antibacterial strategies, the dual activity of photobiomodulation (PBM) and nitric oxide (NO) was combined to provide a tunable, on-demand chronic wound therapeutic. S-nitrosothiol-modified mesoporous silica nanoparticles (RSNO-MSNs) were doped into polyurethane (PU) to demonstrate preliminary utility as an antibacterial wound dressing treatment for chronic wounds. Photoinitiated and resultant NO-release kinetics and payloads were evaluated at 405, 430, and 530 nm for multiple irradiances. The use of photons and the NO-releasing MSNs against common chronic wound pathogens, such as Pseudomonas aeruginosa and Staphylococcus aureus, proved to be highly bactericidal. Cytocompatibility of the treatment was confirmed using human epidermal keratinocytes, a representative skin cell line.

引用

页码：1510 / 1522

页数：13

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