Synergistic photothermal and chemo-therapeutic platform utilizing Cu2-xSe/PDA/AIPH nanoparticles for targeted tumor eradication

被引：0
|
作者：
Cheng, Haoyan [1 ,2 ]
Ma, Beng [1 ]
Xia, Wanting [2 ]
Yu, Ying [3 ]
Li, Jiayi [3 ]
Zhang, Keke [1 ]
Shi, Linlin [3 ]
Hu, Hao [1 ]
Gao, Shegan [3 ]
Zhu, Zhihong [2 ]
机构：
[1] Henan Univ Sci & Technol, Affiliated Hosp 1, Sch Mat Sci & Engn, Luoyang 471023, Peoples R China
[2] Cent China Normal Univ, Coll Phys Sci & Technol, Wuhan 430079, Peoples R China
[3] Henan Univ Sci & Technol, Henan Key Lab Microbiome & Esophageal Canc Prevent, Henan Key Lab Canc Epigenet, Affiliated Hosp 1, Luoyang 471003, Peoples R China
来源：
BIOMATERIALS ADVANCES | 2025年 / 169卷
基金：
中国国家自然科学基金;
关键词：
Cu2-xSe/PDA/AIPH; Photothermal therapy; Cytotoxic alkyl radicals; Tumor treatment; NEAR-INFRARED LIGHT; NANOCRYSTALS; APOPTOSIS; SURFACE; STRESS; ROS;
D O I：
10.1016/j.bioadv.2025.214196
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
In this study, we developed an innovative Cu2-xSe/PDA/AIPH nanoparticle platform that combines photothermal therapy and chemotherapy for effective tumor treatment. The Cu2-xSe nanoparticles, known for their strong near- infrared (NIR) absorption, were encapsulated within a polydopamine (PDA) and 2,2 '-azobis[2-(2-imidazolin-2- yl)propane] dihydrochloride (AIPH) matrix. Upon NIR irradiation, the platform triggers localized heating and subsequent thermal decomposition of AIPH, releasing ROS to induce significant oxidative damage in tumor cells. In vitro and in vivo experiments demonstrated that Cu2-xSe/PDA/AIPH nanoparticles exhibit excellent biocompatibility, effective photothermal conversion, and potent anticancer efficacy. This multifunctional nanosystem offers a promising approach for enhancing tumor therapy by combining PTT with ROS-mediated chemotherapy.
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页数：9
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