Annoglabrin A-C, three new ent-kaurane diterpenoids from the Annona glabra fruit pulp

被引：0

作者：

Duong, Thi-Kim-Yen ^{[1
,2
]}

Nguyen, Van-Kieu ^{[3
,4
]}

Dao, Ngoc-Van-Trang ^{[5
,6
]}

Bui, Xuan-Hang ^{[7
]}

Thao, Vo Thi Minh ^{[8
]}

Nguyen, Minh-Khanh ^{[8
]}

Dong, Phan-Si-Nguyen ^{[3
,4
]}

Phan, Hoang-Vinh-Truong ^{[3
,4
]}

Tran, Thanh-Nha ^{[9
]}

Ngo, Hoang-Ngoc-Thanh ^{[3
,4
]}

Mai, Dinh-Tri ^{[1
,10
]}

Hoang, Le-Thuy-Thuy-Trang ^{[11
,12
]}

机构：

[1] Vietnam Acad Sci & Technol, Grad Univ Sci & Technol, Hanoi, Vietnam

[2] Pham Ngoc Thach Univ Med, Dept Chem & Biochem, Ho Chi Minh City, Vietnam

[3] Duy Tan Univ, Inst Fundamental & Appl Sci, Ho Chi Minh City, Vietnam

[4] Duy Tan Univ, Fac Nat Sci, Da Nang, Vietnam

[5] Duy Tan Univ, Inst Res & Dev, Da Nang, Vietnam

[6] Duy Tan Univ, Sch Engn & Technol, Da Nang, Vietnam

[7] Int Univ, Dept Biotechnol, Ho Chi Minh City, Vietnam

[8] Biotechnol Ctr Ho Chi Minh City, Ho Chi Minh City, Vietnam

[9] Thu Dau Mot Univ, Dept Environm Engn, Binh Duong, Vietnam

[10] Vietnam Acad Sci & Technol, Inst Chem Technol, Ho Chi Minh City, Vietnam

[11] Ton Duc Thang Univ, Inst Adv Study Technol, Lab Adv Mat Chem, Ho Chi Minh City, Vietnam

[12] Ton Duc Thang Univ, Fac Appl Sci, Ho Chi Minh City, Vietnam

来源：

NATURAL PRODUCT RESEARCH | 2024年

关键词：

Annona glabra; annoglabrin; ent-kaurane diterpenoid; MONO-TETRAHYDROFURAN ACETOGENINS; CHEMICAL-CONSTITUENTS;

D O I：

10.1080/14786419.2024.2414397

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three new ent-kaurane diterpenoids, namely annoglabrin A-C (1-3), were isolated from the Annona glabra fruit pulp. Their structures were clarified by widespread spectroscopic analyses (1D and 2D NMR, HRESIMS). The relative configuration of these new compounds was established through the NOESY spectrum. Compounds 1-3 were evaluated for their inhibitory activity against alpha-glucosidase and were found with weak (1 and 3) or no effects (2), compared to those of positive control (acarbose, IC50 82.0 mu M).

引用

页数：9

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