Dynamic visualization of endoplasmic reticulum viscosity in living cells with a multirotor-based fluorescent probe

被引：0
|
作者：
Zhang, Yuehua [1 ,2 ]
Dong, Nuo [1 ,2 ]
Nan, Shiyu [1 ,2 ]
Dang, Huijie [2 ]
Cheng, Yuan [2 ]
Lu, Liqing [3 ]
Wang, Mei [2 ]
Zhang, Pingzhu [1 ,2 ]
Chen, Hua [1 ,2 ]
Wei, Chao [1 ,2 ]
机构：
[1] Hebei Univ, Key Lab Med Chem & Mol Diag, Key Lab Chem Biol Hebei Prov, Minist Educ, Baoding 071002, Peoples R China
[2] Hebei Univ, Coll Chem & Mat Sci, Baoding 071002, Peoples R China
[3] Hebei Univ, Sch Basic Med Sci, Baoding 071002, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2025年 / 61卷 / 25期
关键词：
MITOCHONDRIA;
D O I：
10.1039/d5cc00365b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Changes in viscosity can significantly influence the functionality of the endoplasmic reticulum (ER), and viscosity-responsive fluorescent probes can provide valuable feedback on its physiological state. In this study, three multirotor-based fluorescent probes (1-3) were designed and synthesized. Probes 1 and 2 exhibited remarkable viscosity sensitivity and specific targeting ability towards the ER. Probe 1 was utilized for in situ dynamic visualization of ER viscosity changes during inflammatory responses, drug treatments, and reticulophagy.
引用
收藏
页码：4804 / 4807
页数：4
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