Overcoming immune evasion with innovative multi-target approaches for glioblastoma

被引：0
|
作者：
Su, Hai [1 ]
Peng, Yin [1 ]
Wu, Yilong [1 ]
Zeng, Xiaoli [2 ,3 ,4 ]
机构：
[1] Chongqing Med Univ, Dept Neurosurg, Yongchuan Hosp, Chongqing, Peoples R China
[2] Gannan Med Univ, Affiliated Hosp 1, Dept Oncol, Ganzhou, Jiangxi, Peoples R China
[3] Gannan Med Univ, Affiliated Hosp 1, Jiangxi Flagship Oncol Dept Synergy Chinese & West, Ganzhou, Jiangxi, Peoples R China
[4] Gannan Med Univ, Affiliated Hosp 1, Jiangxi Clin Med Res Ctr Canc, Dept Oncol, Ganzhou, Jiangxi, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2025年 / 16卷
关键词：
glioblastoma; immune evasion; immunotherapy; PD-1; immune checkpoint; TUMOR-INFILTRATING LYMPHOCYTES; RANDOMIZED PHASE-III; REGULATORY T-CELLS; INDOLEAMINE 2,3-DIOXYGENASE; RECURRENT GLIOBLASTOMA; INHIBITORY MOLECULES; CHECKPOINT BLOCKADE; UP-REGULATION; GLIOMA; EXPRESSION;
D O I：
10.3389/fimmu.2025.1541467
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Glioblastoma (GBM) cells leverage complex endogenous and environmental regulatory mechanisms to drive proliferation, invasion, and metastasis. Tumor immune evasion, facilitated by a multifactorial network, poses a significant challenge to effective therapy, as evidenced by the limited clinical benefits of monotherapies, highlighting the adaptive nature of immune evasion. This review explores glioblastoma's immune evasion mechanisms, the role of ICIs in the tumor microenvironment, and recent clinical advancements, offering theoretical insights and directions for monotherapy and combination therapy in glioblastoma management.
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页数：8
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