Scandium(III)-Catalyzed N-Alkylation of Carbazoles with Alcohols

被引：0
|
作者：
Niu, Yu-Dan [1 ]
Lv, Pei [2 ]
Hu, Hao-Lan [1 ]
Shi, Jianghuan [2 ]
Chen, Peng [1 ]
Jiang, Yi-Jun [1 ]
机构：
[1] Ningbo Univ, Sch Mat Sci & Chem Engn, Key Lab Adv Mass Spectrometry & Mol Anal Zhejiang, Inst Mass Spectrometry, Ningbo 315211, Zhejiang, Peoples R China
[2] Ningbo Inst Measurement & Testing, Ningbo Inspect & Testing Ctr New Mat, Ningbo 315048, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2025年 / 57卷 / 06期
关键词：
N-alkylation; carbazoles; benzylic alcohols; scandium-catalysis; heterocycles; DERIVATIVES;
D O I：
10.1055/a-2502-7704
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general and efficient protocol has been developed for the N-alkylation of carbazoles with benzylic alcohols via scandium-catalyzed reaction. This transformation proceeds smoothly under an air atmosphere and features simple reaction conditions and wide substrate scope, which deliver a variety of N-alkylated carbazoles with up to 99%yields and broad functional group compatibilities.
引用
收藏
页码：1223 / 1229
页数：7
相关论文
共 50 条
  • [11] Solvent-Free N-Alkylation of Amides with Alcohols Catalyzed by Nickel on Silica-Alumina
    Charvieux, Aubin
    Le Moigne, Louis
    Borrego, Lorenzo G.
    Duguet, Nicolas
    Metay, Estelle
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2019, 2019 (40) : 6842 - 6846
  • [12] Iron-Catalyzed N-Alkylation of Secondary Amines with Alcohols Using Borrowing Hydrogen Strategy
    Qu, Ruxin
    Cheng, Yaxuan
    Yang, Siwei
    Zhao, Chaoyu
    Liu, Huiling
    Huang, Xuri
    CHEMISTRYSELECT, 2021, 6 (17): : 4089 - 4097
  • [13] Rh(III)-Catalyzed Direct ortho Alkylation of Carbazoles with Nitroalkenes
    Zhang, Liming
    Zhao, Ru
    Liu, Chunhui
    Li, Zhaoyang
    Niu, Jun-Long
    Yang, Hao-Ran
    Gao, Lijun
    Liu, Shuang-Liang
    Zhou, Liming
    ADVANCED SYNTHESIS & CATALYSIS, 2023, 365 (20) : 3461 - 3466
  • [14] Zinc-Catalyzed N-Alkylation of Aromatic Amines with Alcohols: A Ligand-Free Approach
    Sankar, Velayudham
    Kathiresan, Murugavel
    Sivakumar, Bitragunta
    Mannathan, Subramaniyan
    ADVANCED SYNTHESIS & CATALYSIS, 2020, 362 (20) : 4409 - 4414
  • [15] Highly Efficient and Selective N-Alkylation of Amines with Alcohols Catalyzed by in Situ Rehydrated Titanium Hydroxide
    Niu, Feng
    Wang, Qiyan
    Yan, Zhen
    Kusema, Bright T.
    Khodakov, Andrei Y.
    Ordomsky, Vitaly V.
    ACS CATALYSIS, 2020, 10 (05) : 3404 - 3414
  • [16] Heterogeneously catalyzed selective N-alkylation of aromatic and heteroaromatic amines with alcohols by a supported ruthenium hydroxide
    Kim, Jung Won
    Yamaguchi, Kazuya
    Mizuno, Noritaka
    JOURNAL OF CATALYSIS, 2009, 263 (01) : 205 - 208
  • [17] Microwave-assisted N-alkylation of amines with alcohols catalyzed by MnCl2: Anticancer, docking, and DFT studies
    Kumar, K. Yogesh
    Kumar, C. B. Pradeep
    Prasad, K. N. N.
    Jeon, Byong-Hun
    Alsalme, Ali
    Prashanth, M. K.
    ARCHIV DER PHARMAZIE, 2022, 355 (05)
  • [18] Selective N-Alkylation of Indoles with α,β-Unsaturated Compounds Catalyzed by a Monomeric Phosphate
    Sunaba, Hanako
    Kamata, Keigo
    Mizuno, Noritaka
    CHEMCATCHEM, 2014, 6 (08) : 2333 - 2338
  • [19] Organophotoredox-Catalyzed Decarboxylative N-Alkylation of Sulfonamides
    Nakagawa, Masanari
    Nagao, Kazunori
    Ikeda, Zenichi
    Reynolds, Matthew
    Ibanez, Ignacio
    Wang, Junsi
    Tokunaga, Norihito
    Sasaki, Yusuke
    Ohmiya, Hirohisa
    CHEMCATCHEM, 2021, 13 (18) : 3930 - 3933
  • [20] Regioselective N-alkylation of 2-aminobenzothiazoles with benzylic alcohols
    Li, Feng
    Shan, Haixia
    Kang, Qikai
    Chen, Lin
    CHEMICAL COMMUNICATIONS, 2011, 47 (17) : 5058 - 5060
12345