Lymphoproliferative Disorder in an Esophageal Cancer Patient Treated with Pembrolizumab

被引：1
作者：
Matsumura, Takashi [1 ]
Tsuchihashi, Kenji [1 ]
Yamamoto, Takeo [2 ]
Jinnouchi, Fumiaki [1 ]
Kusano, Wataru [1 ]
Kusumoto, Yota [1 ]
Arimizu, Kohei [1 ]
Ohmura, Hirofumi [3 ]
Kuma, Yuki [4 ]
Moriyama, Shohei [1 ]
Yamaguchi, Kyoko [5 ]
Ito, Mamoru [1 ]
Isobe, Taichi [3 ]
Ariyama, Hiroshi [1 ]
Oda, Yoshinao [2 ]
Akashi, Koichi [1 ]
Baba, Eishi [3 ]
机构：
[1] Kyushu Univ Hosp, Dept Hematol Oncol & Cardiovasc Med, Fukuoka, Japan
[2] Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol, Kyushu, Japan
[3] Kyushu Univ, Grad Sch Med Sci, Dept Comprehens Oncol, Kyushu, Japan
[4] Kyushu Univ, Grad Sch Med Sci, Dept Dermatol, Fukuoka, Japan
[5] Kyushu Univ, Grad Sch Med Sci, Dept Med Educ, Fukuoka, Japan
来源：
INTERNAL MEDICINE | 2024年
关键词：
Lymph proliferative disorders; EBV; Pembrolizumab; Immune checkpoint inhibitor; RHEUMATOID-ARTHRITIS; METHOTREXATE; LYMPHOMA;
D O I：
10.2169/internalmedicine.3743-24
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 75-year-old man diagnosed with esophageal cancer and lung metastasis received a combination of fluorouracil, cisplatin, and pembrolizumab. During pembrolizumab maintenance therapy, lymphoproliferative lesions at the lips and mouth and multiple lymph node swellings appeared. Histologically, Epstein-Barr virus (EBV)-encoded RNA was positive, and EBV-DNA was detected in the blood. The patient was diagnosed with other iatrogenic immunodeficiency-associated lymph proliferative disorders (OIIA-LPDs) related to EBV activation induced by pembrolizumab. Rituximab was administered, resulting in the improvement of the OIIA-LPD. The emergence of an OIIA-LPD merits close attention in patients receiving immune checkpoint inhibitors.
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页数：5
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