Lymphoproliferative Disorder in an Esophageal Cancer Patient Treated with Pembrolizumab

被引：1
作者：
Matsumura, Takashi [1 ]
Tsuchihashi, Kenji [1 ]
Yamamoto, Takeo [2 ]
Jinnouchi, Fumiaki [1 ]
Kusano, Wataru [1 ]
Kusumoto, Yota [1 ]
Arimizu, Kohei [1 ]
Ohmura, Hirofumi [3 ]
Kuma, Yuki [4 ]
Moriyama, Shohei [1 ]
Yamaguchi, Kyoko [5 ]
Ito, Mamoru [1 ]
Isobe, Taichi [3 ]
Ariyama, Hiroshi [1 ]
Oda, Yoshinao [2 ]
Akashi, Koichi [1 ]
Baba, Eishi [3 ]
机构：
[1] Kyushu Univ Hosp, Dept Hematol Oncol & Cardiovasc Med, Fukuoka, Japan
[2] Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol, Kyushu, Japan
[3] Kyushu Univ, Grad Sch Med Sci, Dept Comprehens Oncol, Kyushu, Japan
[4] Kyushu Univ, Grad Sch Med Sci, Dept Dermatol, Fukuoka, Japan
[5] Kyushu Univ, Grad Sch Med Sci, Dept Med Educ, Fukuoka, Japan
来源：
INTERNAL MEDICINE | 2024年
关键词：
Lymph proliferative disorders; EBV; Pembrolizumab; Immune checkpoint inhibitor; RHEUMATOID-ARTHRITIS; METHOTREXATE; LYMPHOMA;
D O I：
10.2169/internalmedicine.3743-24
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 75-year-old man diagnosed with esophageal cancer and lung metastasis received a combination of fluorouracil, cisplatin, and pembrolizumab. During pembrolizumab maintenance therapy, lymphoproliferative lesions at the lips and mouth and multiple lymph node swellings appeared. Histologically, Epstein-Barr virus (EBV)-encoded RNA was positive, and EBV-DNA was detected in the blood. The patient was diagnosed with other iatrogenic immunodeficiency-associated lymph proliferative disorders (OIIA-LPDs) related to EBV activation induced by pembrolizumab. Rituximab was administered, resulting in the improvement of the OIIA-LPD. The emergence of an OIIA-LPD merits close attention in patients receiving immune checkpoint inhibitors.
引用
收藏
页数：5
相关论文
共 50 条
  • [21] A case of bilateral uveitis and papillitis in a patient treated with pembrolizumab
    Abu Samra, Khawla
    Valdes-Navarro, Manuel
    Lee, Stacey
    Swan, Robert
    Foster, C. Stephen
    Anesi, Stephen D.
    EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2016, 26 (03) : E46 - E48
  • [22] Delayed onset autoimmune cholangitis in a patient treated with pembrolizumab
    Newington, Joshua
    Patterson, Daniel
    Sanchez, Pilar
    BJR CASE REPORTS, 2024, 10 (06):
  • [23] Pulmonary pleomorphic carcinoma in an elderly patient treated with pembrolizumab shows a marked response
    Yamasaki, Masahiro
    Matsumoto, Yu
    Nakamoto, Kanako
    Hattori, Noboru
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2021, 17 (06) : 1580 - 1582
  • [24] A pathological complete response and adrenal insufficiency in a patient with advanced renal pelvic cancer treated with pembrolizumab
    Suzuki, Kotaro
    Murata, Kazuki
    Wakita, Naoto
    Terakawa, Tomoaki
    Nakanishi, Takaaki
    Hara, Takuto
    Hyodo, Yoji
    Chiba, Koji
    Teishima, Jun
    Nakano, Yuzo
    Miyake, Hideaki
    INTERNATIONAL CANCER CONFERENCE JOURNAL, 2024, 13 (04): : 391 - 394
  • [25] The management of posttransplant lymphoproliferative disorder
    Frey, Noelle V.
    Tsai, Donald E.
    MEDICAL ONCOLOGY, 2007, 24 (02) : 125 - 136
  • [26] METHOTREXATE-ASSOCIATED LYMPHOPROLIFERATIVE DISORDER PRESENTING AS ORAL ULCERS IN A PATIENT WITH RHEUMATOID ARTHRITIS
    Pastor-Nieto, M. A.
    Kilmurray, L. G.
    Lopez-Chumillas, A.
    O'Valle, F.
    Moral, R. Garcia-del
    Puig, A. M.
    Bautista, P.
    ACTAS DERMO-SIFILIOGRAFICAS, 2009, 100 (02): : 142 - 146
  • [27] Methotrexate-associated orbital lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report
    Kobayashi, Yuka
    Kimura, Kazuhiro
    Fujitsu, Youichiro
    Shinkawa, Kuniisa
    Muta, Hiroko
    Sonoda, Koh-Hei
    JAPANESE JOURNAL OF OPHTHALMOLOGY, 2016, 60 (03) : 212 - 218
  • [28] Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Polymyalgia Rheumatica Presenting with Double Vision
    Berman, Gabriele
    Amel-Kashipaz, Rasoul
    Mahendra, Prem
    Ramalingam, Satheesh
    Rhodes, Benjamin
    Mollan, Susan
    Patil, Ajay
    NEURO-OPHTHALMOLOGY, 2025, 49 (01) : 75 - 82
  • [29] The management of posttransplant lymphoproliferative disorder
    Noelle V. Frey
    Donald E. Tsai
    Medical Oncology, 2007, 24 : 125 - 136
  • [30] Methotrexate-associated Lymphoproliferative Disorder in the Liver Resembling Hepatocellular Carcinoma Treated with Transarterial Chemoembolization
    Tsuruoka, Mio
    Inoue, Jun
    Kakazu, Eiji
    Ninomiya, Masashi
    Iwata, Tomoaki
    Sano, Akitoshi
    Masamune, Atsushi
    INTERNAL MEDICINE, 2020, 59 (18) : 2255 - 2260
12345