Lymphoproliferative Disorder in an Esophageal Cancer Patient Treated with Pembrolizumab

被引：1

作者：

Matsumura, Takashi ^{[1
]}

Tsuchihashi, Kenji ^{[1
]}

Yamamoto, Takeo ^{[2
]}

Jinnouchi, Fumiaki ^{[1
]}

Kusano, Wataru ^{[1
]}

Kusumoto, Yota ^{[1
]}

Arimizu, Kohei ^{[1
]}

Ohmura, Hirofumi ^{[3
]}

Kuma, Yuki ^{[4
]}

Moriyama, Shohei ^{[1
]}

Yamaguchi, Kyoko ^{[5
]}

Ito, Mamoru ^{[1
]}

Isobe, Taichi ^{[3
]}

Ariyama, Hiroshi ^{[1
]}

Oda, Yoshinao ^{[2
]}

Akashi, Koichi ^{[1
]}

Baba, Eishi ^{[3
]}

机构：

[1] Kyushu Univ Hosp, Dept Hematol Oncol & Cardiovasc Med, Fukuoka, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol, Kyushu, Japan

[3] Kyushu Univ, Grad Sch Med Sci, Dept Comprehens Oncol, Kyushu, Japan

[4] Kyushu Univ, Grad Sch Med Sci, Dept Dermatol, Fukuoka, Japan

[5] Kyushu Univ, Grad Sch Med Sci, Dept Med Educ, Fukuoka, Japan

来源：

INTERNAL MEDICINE | 2024年

关键词：

Lymph proliferative disorders; EBV; Pembrolizumab; Immune checkpoint inhibitor; RHEUMATOID-ARTHRITIS; METHOTREXATE; LYMPHOMA;

D O I：

10.2169/internalmedicine.3743-24

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 75-year-old man diagnosed with esophageal cancer and lung metastasis received a combination of fluorouracil, cisplatin, and pembrolizumab. During pembrolizumab maintenance therapy, lymphoproliferative lesions at the lips and mouth and multiple lymph node swellings appeared. Histologically, Epstein-Barr virus (EBV)-encoded RNA was positive, and EBV-DNA was detected in the blood. The patient was diagnosed with other iatrogenic immunodeficiency-associated lymph proliferative disorders (OIIA-LPDs) related to EBV activation induced by pembrolizumab. Rituximab was administered, resulting in the improvement of the OIIA-LPD. The emergence of an OIIA-LPD merits close attention in patients receiving immune checkpoint inhibitors.

引用

页数：5

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