CD19 CAR-T cell therapy: a new dawn for autoimmune rheumatic diseases?

被引：2

作者：

Rangel-Pelaez, Carlos ^{[1
]}

Martinez-Gutierrez, Laura ^{[1
]}

Tristan-Manzano, Maria ^{[2
]}

Callejas, Jose Luis ^{[3
,4
]}

Ortego-Centeno, Norberto ^{[3
,4
]}

Martin, Francisco ^{[5
,6
,7
]}

Martin, Javier ^{[1
]}

机构：

[1] CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada, Spain

[2] Pfizer Univ Granada Andalusian Reg Govt Ctr Genom, LentiStem Biotech, Granada, Spain

[3] Hosp Clin San Cecilio, Syst Autoimmune Dis Unit, Inst Invest Biosanit Ibs, Granada, Spain

[4] Univ Granada, Dept Med, Granada, Spain

[5] Univ Granada, Fac Med, Dept Biochem & Mol Biol & Immunol 3, Inst Biosanitario Granada ibs GRANADA, Granada, Spain

[6] Pfizer Univ Granada Andalusian Reg Govt Ctr Genom, Dept Genom Med, Granada, Spain

[7] Univ Granada, Inst Biosanitario Granada ibs GRANADA, Granada, Spain

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

关键词：

CD19; CAR-T; autoimmune rheumatic diseases; systemic lupus erythematosus; systemic sclerosis; rheumatoid arthritis; SYSTEMIC-LUPUS-ERYTHEMATOSUS; TARGETED THERAPY; B-CELLS; EFFICACY; TISAGENLECLEUCEL; IMMUNOGLOBULIN; FLUDARABINE; RITUXIMAB; VECTORS; PROMISE;

D O I：

10.3389/fimmu.2024.1502712

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune rheumatic diseases (ARDs), such as rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis, involve dysregulated immune responses causing chronic inflammation and tissue damage. Despite advancements in clinical management, many patients do not respond to current treatments, which often show limited efficacy due to the persistence of autoreactive B cells. Chimeric antigen receptor (CAR)-T cell therapy, which has shown success in oncology for B cell malignancies, targets specific antigens and involves the adoptive transfer of genetically engineered T cells. CD19 CAR-T cells, in particular, have shown promise in depleting circulating B cells and achieving clinical remission. This review discusses the potential of CD19 CAR-T cells in ARDs, highlighting clinical achievements and addressing key considerations such as optimal target cell populations, CAR construct design, acceptable toxicities, and the potential for lasting immune reset, crucial for the safe and effective adoption of CAR-T cell therapy in autoimmune treatments.

引用

页数：12

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