Evaluation of antioxidant, antimicrobial, antidiabetic, anti-tyrosinase, and neuroprotective effects of (1-ionone: in vitro and in silico analysis

被引：0

作者：

Touhtouh, Jihane ^{[1
]}

Laghmari, Mustapha ^{[1
]}

Benali, Taoufiq ^{[1
,2
]}

Aanniz, Tarik ^{[3
]}

Akhazzane, Mohamed ^{[4
]}

Goh, Khang Wen ^{[5
,6
]}

Al Abdulmonem, Waleed ^{[7
]}

Bouyahya, Abdelhakim ^{[8
]}

Zengin, Gokhan ^{[9
]}

Hammani, Khalil ^{[1
]}

机构：

[1] Sidi Mohammed Ben Abdellah Univ, Multidisciplinary Fac Taza, Nat Resources & Environm Lab, Fes 30000, Morocco

[2] Cadi Ayyad Univ, Polydisciplinary Fac Safi, Environm & Hlth Team, Safi, Morocco

[3] Mohammed V Univ Rabat, Rabat Med & Pharm Sch, Med Biotechnol Lab Medbiotech, Rabat, Morocco

[4] Sidi Mohamed Ben Abdellah Univ, Fac Sci Dhar Mahraz, Engn Lab Organometall Mol Mat & Environm, POB 1796, Atlas 30000, Morocco

[5] INTI Int Univ, Fac Data Sci & Informat Technol, Nilai, Malaysia

[6] Univ Negeri Padang, Fac Math & Nat Sci, Padang, Indonesia

[7] Qassim Univ, Coll Med, Dept Pathol, Buraydah, Saudi Arabia

[8] Mohammed V Univ Rabat, Fac Sci, Dept Biol, Lab Human Pathol Biol, Rabat 10106, Morocco

[9] Selcuk Univ, Sci Fac, Dept Biol, Physiol & Biochem Res Lab, TR-42130 Konya, Turkiye

来源：

RESULTS IN CHEMISTRY | 2024年 / 12卷

关键词：

beta-Ionone; Antioxidants; Enzyme activity; Antimicrobial activity; Molecular docking simulation; NF-KAPPA-B; PERSISTENT PRENEOPLASTIC LESIONS; BETA-IONONE; EXTRACTS; TOBACCO; CELLS; HEPATOCARCINOGENESIS; CARCINOGENESIS; RESISTANCE; INHIBITORS;

D O I：

10.1016/j.rechem.2024.101874

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(1-Ionone is a bioactive phytochemical that has been extracted from many flowers, vegetables, and fruits. (1-Ionone is an intriguing lead molecule from which several derivatives have been generated and exhibiting a variety of biological effects. Here, we investigated the (1-Ionones' antioxidant, anti-cholinesterases (AChE and BChE), anti-alpha-amylase, anti-alpha-glucosidase, and anti-tyrosinase activities. The antibacterial and antifungal effects were also studied. Moreover, in silico studies using molecular docking were carried out to understand the obtained results. The antioxidant activity performed by six different assays including phosphomolybdenum, CUPRAC, FRAP, DPPH, ABTS and metal chelating assay showed that (1-Ionone exhibits a promising antioxidant activity. Besides, a good inhibition of AChE and BChE, as well as a-glucosidase, a-amylase, and tyrosinase was obtained. Molecular docking evidenced that (1-Ionone correctly occupied the active site of the five studied enzymes through various kind of interactions which corroborate the in vitro outcomes. Moreover, in silico ADMET assessment showed that (1-Ionone presented a good ADMET profile. Gram positive bacteria, specifically S. aureus (DIZ = 25 f 1.5 mm; MIC = 6.25 mg/mL; CMB = 6.25 mg/mL) and B. cereus (DIZ = 21.5 f 1 mm; MIC = 0.78 mg/mL; CMB = 0.78 mg/mL), showed greater susceptibility. Regarding Gram negative ones, P. aeruginosa exhibited also marked sensitivity (DIZ = 20.33 f 1.5 mm; MIC = 12.5 mg/mL; CMB = 12.5 mg/mL). Additionally, (1-Ionone can limit the growth of C. albicans (DIZ = 23 f 1 mm; MIC = 1.56 mg/mL; CMB = 1.56 mg/ mL). A bactericidal and fungicidal efficacy could be suggested as the MBC/MIC towards all the four inhibited pathogens was equal to 1. To sum up, data suggested that (1-Ionone could have potential applications as an antioxidant, antimicrobial, and antifungal compound, as well as a potential inhibitor of tyrosinase, alpha-amylase, alpha-glucosidase, and cholinesterases. Furthermore, it can serve as a lead chemical in the creation of a new semisynthetic drug intended in order to treat numerous illnesses, including diabetes, Alzheimer's disease, and pigmentation disorders.

引用

页数：8