Original Antigenic Sin on Antibody Response in SARS-CoV-2 Infection

被引:0
|
作者
Wang, Miao [1 ]
Guo, Huimin [1 ]
Ju, Bin [1 ,2 ]
Zhang, Zheng [1 ,2 ,3 ]
机构
[1] Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Inst Hepatol,Sch Med ,Natl Clin Res Ctr Infect Dis, Shenzhen 518112, Guangdong Provi, Peoples R China
[2] Guangdong Key Lab Antiinfect Drug Qual Evaluat, Shenzhen 518112, Guangdong Provi, Peoples R China
[3] Chinese Acad Med Sci, Shenzhen Res Ctr Communicable Dis Diag & Treatment, Shenzhen 518112, Guangdong Provi, Peoples R China
来源
INFECTIOUS DISEASES & IMMUNITY | 2024年 / 4卷 / 03期
基金
中国国家自然科学基金;
关键词
SARS-CoV-2; Original antigenic sin; Antibody response; Omicron subvariants; Vaccine design; CELLS;
D O I
10.1097/ID9.0000000000000125
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Infection and vaccination can provide protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the emergence of SARS-CoV-2 variants has persisted, leading to breakthrough infections. Owing to the original antigenic sin (OAS), variant breakthrough infection or vaccination potentially induces a stronger antibody response against the ancestral strain than to subsequent variants, as in the case of influenza. Thus, overcoming OAS is important for the development of future vaccine designs. This review summarizes the recent findings on OAS in the antibody response to SARS-CoV-2 and its variants, with an emphasis on future vaccine designs.
引用
收藏
页码:132 / 137
页数:6
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